Antiglucocorticoids: in vivo assay and evaluation of cortexolone, progesterone, and 6-beta-bromoprogesterone

Endocrinology
P H NaylorF Rosen

Abstract

In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexamethasone in the liver of adrenalectomized rats but did not significantly influence the induced TAT activity. Progesterone, although toxic at levels approaching those used for cortexolone, was capable of antagonizing the glycogen increase. A new antagonist, 6 beta-bromoprogesterone, was found to be nontoxic and was more potent than cortexolone in blocking the TPO and glycogen responses. These results demonstrate that in vivo antiglucocorticoid activity can be evaluated and suggested significant differences between the sensitivity of TAT induction and that of glycogen or TPO.

Citations

Jun 15, 1987·FEBS Letters·M K AgarwalG Lazer
Mar 1, 1983·Journal of Steroid Biochemistry·G G RousseauJ P Schmit
Sep 1, 1985·Journal of Steroid Biochemistry·D GagneD Philibert
Oct 1, 1988·Journal of Steroid Biochemistry·W L DuaxZ Wawrzak
Jan 1, 1996·Pharmacology & Therapeutics·M K Agarwai
Aug 30, 1985·Biochimica Et Biophysica Acta·K M KeatingB G Barisas
Jan 1, 1988·International Journal of Immunopharmacology·J R Stevenson, R Taylor
Feb 9, 2000·Pharmacology & Therapeutics·M K Agarwal, M Mirshahi
Aug 1, 1989·Clinical and Experimental Pharmacology & Physiology·C D SpenceB A Scoggins
May 1, 1990·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S S BotrosF A Ebeid
Jul 1, 1985·Acta Pharmacologica Et Toxicologica·H GjerdeN Norman
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·B W M M PeetersG S F Ruigt
Mar 1, 1985·Hypertension·J P GrünfeldM Worcel

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