Jun 1, 1988

Antihaemophilic effect of vasopressin, deamino-(D-arginine8)-vasopressin and adrenaline in sheep: proposal for an in vivo assay system

British Journal of Pharmacology
J HeinigerV Pliska


Female sheep were used to assay antihaemophilic (factor VIII enhancing) activity of arginine vasopressin, deamino-(D-arginine8)-vasopressin (DDAVP) and adrenaline. The time course of the response was biphasic, two surges of factor VIII being observed. DDAVP was found to be the most potent of the substances investigated. Its optimal dose was 1 microgram kg-1 body wt (i.v.). It is suggested that a similar procedure can be employed to search for new peptides with anti-haemophilic action.

Mentioned in this Paper

Antidiuretic Hormone Measurement
Dall Sheep
F8 gene
Factor VIII Procoagulant Activity
Factor VIII Measurement
Epinephrine Measurement
Antihemophilic Factor, Human Recombinant

About this Paper

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