Antihistamines: do they work? Further well-controlled trials involving larger samples are needed

Allergy
F FumagalliG W Canonica

Abstract

Histamine is one of the most important steps in the phlogistic allergic reaction. Its activity is due to the link to specific receptors on the cellular surface. H1-receptors of second generation are the most currently prescribed drugs in allergic diseases for their high selectivity, little or no central sedative effect, rapid onset of action and long half lives. Antihistamines can modulate part of immunological mechanisms involved in the pathogenesis of allergic inflammation reducing mediator release and expression of adhesion molecules, regulating the release of cytokines, chemokines and consequently inflammatory cells recruitment. The anti-inflammatory effects of cetirizine, desloratadine and levocetirizine are reviewed. Quality of life is considered too, as a main parameter in a global evaluation of the antihistamine's effects.

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Citations

Aug 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Ilaria BaiardiniGiorgio Walter Canonica
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L BarnesB J Lipworth
Sep 28, 2006·Allergy·I BaiardiniG W Canonica
Jun 21, 2014·Allergologia et immunopathologia·E RidoloG W Canonica
Dec 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Naresha SaligramaCory Teuscher
Mar 18, 2021·Brazilian Oral Research·Tatiana Kelly da Silva FidalgoAna Paula Valente

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