Antihistaminic and antiallergic actions of extracts of Solanum nigrum berries: possible role in the treatment of asthma

Journal of Ethnopharmacology
S A NirmalS R Pattan

Abstract

Berries of the plant Solanum nigrum Linn (Solanaceae) are used for the treatment of asthma in folk medicine and ancient books. To evaluate potential of the plant berries in the treatment of asthma. Petroleum ether, ethanol and aqueous extracts of S. nigrum berries (50, 100 and 200mg/kg, i.p.) were screened for the treatment of asthma by the various methods viz. effect on clonidine and haloperidol induced catalepsy, milk-induced leucocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in vitro). Active petroleum ether extract was standardized by HPTLC. The petroleum ether extract of S. nigrum berries inhibited clonidine-induced catalepsy significantly but not haloperidol-induced catalepsy. Petroleum ether extract significantly inhibited increased leukocyte and eosinophil count due to milk allergen and showed maximum protection against mast cell degranulation by clonidine. Petroleum ether extract resisted contraction induced by histamine better than other extracts. All the results are dose dependant. Active petroleum ether extract showed presence of antiasthmatic compound, β-sitosterol. The petroleum ether extract of S. nigrum berries can inhibits paramete...Continue Reading

References

Jul 3, 1990·European Journal of Pharmacology·K OssowskaS Wolfarth
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·S FerréM Casas
Sep 15, 1985·Biochemical Pharmacology·T B CasaleM Kaliner
Oct 1, 1983·The Journal of Pharmacy and Pharmacology·J H JadhavA G Chandorkar
Nov 1, 1980·The Journal of Pharmacy and Pharmacology·A D LakdawalaA N Dohadwalla
Jan 28, 1993·The New England Journal of Medicine·S J Galli
Oct 9, 1999·The European Respiratory Journal·D SchmidtK F Rabe
Jul 25, 2000·Clinics in Chest Medicine·R J Homer, J A Elias
Jun 8, 2001·Journal of Ethnopharmacology·M S HarishS Badami
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J Paul JusticeJames J Lee
Mar 20, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Wei-Qing RangYuan-Jian Li
Feb 11, 2004·Current Allergy and Asthma Reports·Russell P Bowler
Oct 22, 1949·British Medical Journal·H HERXHEIMER
Aug 25, 2010·Pharmaceutical Biology·Yan ChenYifa Zhou
Sep 22, 2010·World Journal of Gastroenterology : WJG·Roja RahimiMohammad Abdollahi
Oct 30, 2010·Journal of Agricultural and Food Chemistry·Hsueh-Chun WangChau-Jong Wang
Jan 21, 2011·Virology Journal·Tariq JavedSheikh Riazuddin
Mar 15, 2011·Parasite : Journal De La Société Française De Parasitologie·H HammamiA Ayadi

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Citations

May 14, 2014·Advances in Pharmacological Sciences·Nelvana Ramalingum, M Fawzi Mahomoodally
Apr 15, 2015·Pharmaceutical Biology·Urmila AswarManoj Aswar
Jul 22, 2017·Journal of Ethnopharmacology·Raimon RiosCamila Alexandrina Figueiredo
Mar 15, 2019·Natural Products and Bioprospecting·Joseph Sakah Kaunda, Ying-Jun Zhang

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