Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: a study on mechanism of action

European Journal of Pharmacology
Umut İrfan ÜçelYusuf Öztürk

Abstract

This study used various experimental pain methods to investigate the effects of subacute mianserin administration on diabetes-induced neuropathic pain in rats. The effect of mianserin on hyperalgesia occurring in connection with peripheral diabetic neuropathy was examined using the Randall-Selitto (mechanical nociceptive stimulus), Hargreaves (thermal nociceptive stimulus), and cold-plate (4°C, thermal nociceptive stimulus) tests. The dynamic plantar aesthesiometer, which measures the threshold values for mechanical stimuli, was used for allodynia studies. Thermal allodynia was evaluated with the warm-plate (38°C) test. At 30 and 45 mg/kg, mianserin effectively improved mechanical and thermal hyperalgesia occurring in connection with diabetic neuropathy. Subacute administration of mianserin also reduced diabetes-associated mechanical and thermal allodynia. The ability of mianserin to reduce diabetic neuropathic pain was comparable to that of pregabalin (10mg/kg). The antihyperalgesic and antiallodynic effects of mianserin were reversed with α-methyl-para-tyrosine methyl ester (AMPT, an inhibitor of catecholamine synthesis), phentolamine (a non-selective α-adrenoceptor antagonist), propranolol (a non-selective β-adrenoceptor ant...Continue Reading

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Citations

Oct 27, 2016·Neuroscience·Mélanie KremerMichel Barrot
Jul 17, 2016·Fundamental & Clinical Pharmacology·Taliha H AydınNazlı Turan
Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mustafa Burak BarbarosÜmide Demir Özkay
Jun 27, 2019·Pharmaceuticals·Daria A BelinskaiaNatalia N Shestakova
Jan 17, 2020·Frontiers in Neuroscience·Lidia BravoJuan Antonio Micó
Jan 9, 2020·Psychopharmacology·Nazlı Turan YücelÜmide Demir Özkay

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