Antihyperglycaemic potential of the water-ethanol extract of Kalanchoe crenata (Crassulaceae).

Journal of Natural Medicines
René KamgangJeanne Ngogang Yonkeu

Abstract

Kalanchoe crenata is a vegetable widely used in Cameroon and largely efficient in the treatment of diabetes mellitus. The effect of the water-ethanol extract of this plant (WEKC) on blood glucose levels was investigated in fasting normal and diet-induced diabetic rats (MACAPOS 1) after a short- and medium-term treatment. Diabetes was induced by submitting Wistar rats to a hypercaloric sucrose diet over 4 months. Six hours after a single oral administration of WEKC, 135 and 200 mg kg(-1) body weight extracts significantly (P < 0.01) reduced the blood glucose levels both in normal and diabetic rats without real dose-dependent effect. During the medium-term treatment, 200 mg kg(-1) WEKC administered daily for 4 weeks significantly reduced blood glucose levels within week 1 (P < 0.05), with a maximum effect at week 4 (-52%, P < 0.01), while maintaining glycaemia within the normal range. All the WEKC-treated diabetic rats exhibited significant (P < 0.01) increase in insulin sensitivity index (K (ITT)) compared with the initial time and to the untreated diabetic animals. Animals treated for 4 weeks exhibited a slight resistance in body-weight gain and decrease in food and water intake. The WEKC activities on all parameters assessed w...Continue Reading

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Citations

Jan 1, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C Lambrigger-SteinerU von Mandach
Dec 22, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Darshee B BaxiA V Ramachandran
Dec 22, 2011·Climacteric : the Journal of the International Menopause Society·D BaxiA V Ramachandran
Mar 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Gregory OndiekiXin He
Apr 17, 2009·Phytotherapy Research : PTR·Anup MaitiRanabir Sahu
Apr 12, 2012·Natural Product Reports·Hsin-Yi HungKuo-Hsiung Lee
Apr 16, 2015·Integrative Cancer Therapies·Ana Paula Simões-WüstUNKNOWN Bryophyllum Collaborative Group
Apr 18, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Paul Aimé NoubissiRené Kamgang

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