Antihyperglycemic drugs use and new-onset atrial fibrillation: A population-based nested case control study

PloS One
Yi-sheng LiouGwo-Ping Jong

Abstract

Currently, the potential risk of atrial fibrillation associated with antihyperglycemic drug use has been a topic of considerable interest. However, it remains uncertain whether different classes of antihyperglycemic drug therapy are associated with the risk of atrial fibrillation risk. Here, we investigated the association between different classes of antihyperglycemic drugs and new-onset atrial fibrillation (NAF). A case-matched study was performed based on the National Health Insurance Program in Taiwan. Patients who had NAF were considered the NAF group and were matched in a 1:4 ratio with patients without NAF, who were assigned to the non-NAF group. Patients were matched according to sex, age, diabetes mellitus duration, index date, and Charlson Comorbidity Index score. We used multivariate logistic regression controlling for potential confounders to examine the association between different classes of antihyperglycemic drug use and the risk of NAF. Overall, we identified 2,882 cases and 11,528 matched controls for the study. After adjusting for sex, age, comorbidities, and concurrent medications, users of biguanides or thiazolidinediones were at a lower risk of developing NAF when compared with non-users (odds ratio [OR] 0...Continue Reading

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Citations

Sep 22, 2019·Medicina·Cristina-Mihaela LăcătușuBogdan-Mircea Mihai
Aug 28, 2020·Journal of Cardiovascular Translational Research·Cevher OzcanZhenping Li
Dec 31, 2019·Journal of Diabetes Research·Dana PrídavkováMarián Mokáň
Nov 26, 2020·Cardiovascular Diabetology·Teerapat NantsupawatNipon Chattipakorn
Feb 1, 2021·Cardiac Electrophysiology Clinics·Satoshi HigaShih-Ann Chen
Aug 20, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Laurent FauchierA John Camm

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