Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats

Phytotherapy Research : PTR
Huan-Ting LiJiping Wang

Abstract

The aim of the study was to investigate the effects of baicalin on blood glucose, insulin and cytokine levels. Rat diabetes was induced by intraperitoneal (i.p.) injection of nicotinamide and streptozotocin. Diabetic rats were dosed with i.p. baicalin or oral metformin daily for 8 days. Blood glucose, insulin and hepatic glycogen were determined using conventional methods. The activity of hepatic hexokinase was determined using a coupled assay with glucose-6-phosphate dehydrogenase. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin were measured by enzyme-linked immunosorbent assay. Administration of baicalin at 50 or 100 mg/kg significantly decreased plasma glucose levels in a dose dependent manner. The serum insulin level was not increased by baicalin treatment. Administration of baicalin at a high dose (100 mg/kg) resulted in a significant increase of liver glycogen content and a reduction of serum TNF-α. The activity of hepatic hexokinase was significantly increased after dosing baicalin at 25, 50 or 10 mg/kg. Administration of baicalin (50 or 10 mg/kg) or metformin (10 mg/kg) significantly alleviated the morphological injury to the pancreas caused by STZ. The possible mechanisms contribu...Continue Reading

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Citations

Jan 6, 2011·Diabetes, Obesity & Metabolism·W Xie, L Du
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Huiying LiXiaolin Tong
Dec 1, 2012·Current Therapeutic Research, Clinical and Experimental·Quan YiJian-Dong Luo
Jan 31, 2018·International Journal of Genomics·Jing HanYan Wu
Apr 13, 2013·Phytotherapy Research : PTR·Chunhua MaShiping Ma
Dec 24, 2014·Acta Physiologica Hungarica·Asghar GhasemiS Jedi
Sep 14, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Ting HuangChengliang Zhang
Nov 8, 2018·The Journal of Endocrinology·Gen ChenLitai Jin
Feb 6, 2020·Pharmacological Reports : PR·Penghua FangZhenwen Zhang
Sep 2, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Penghua FangLe Bu
Jun 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ji-Won NohByung-Cheol Lee

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