Antihyperlipidemic activity of Salacia chinensis root extracts in triton-induced and atherogenic diet-induced hyperlipidemic rats.

Indian Journal of Pharmacology
Mukesh S Sikarwar, M B Patil

Abstract

The aim of this study has been to investigate the possible antihyperlipidemic effect of Salacia chinensis root extract in triton (400mg/kg b.w.)-induced and atherogenic diet-induced hyperlipidemic rats. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of Salacia chinensis roots were evaluated for antihyperlipidemic activity in triton- and atherogenic diet-induced hyperlipidemic rats. A comparison was also made between the action of Salacia chinensis root extract and a known antihyperlipidemic drug simvastatin (10 mg/kg body wt.). The results of the study were expressed as mean± S.E. and data was analyzed by using one way analysis of variance test (ANOVA) followed by Dunnett's t-test for multiple comparisons. Values with P < 0.05 were considered as significant. Oral administration of 500 mg/kg body wt. of the chloroform extract and alcoholic extract of Salacia chinensis root exhibited a significant reduction (P<0.01) in serum lipid parameters like total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase in high density lipoprotein (HDL) in hyperlipidemic rats of both models as compared to hyperlipidemic control statistically. These extracts were found t...Continue Reading

Citations

Sep 6, 2018·The Journal of Pharmacy and Pharmacology·Gaurav GargAmitava Chakrabarti
Sep 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rajendran Vijayakumar, Vasanthi Nachiappan
Jan 12, 2021·Saudi Journal of Biological Sciences·Sayeed Mohammed FirdousMourad A M Aboul-Soud

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