Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice

Journal of Ethnopharmacology
Yonglan MaZhiqi Yin

Abstract

Cyclocarya paliurus (CP) Batal., the sole species in its genus, is a native plant to China. As a traditional Chinese folk medicine, the tree leaves have been widely used for the treatment of metabolic disorders, including hyperlipidemia, obesity, diabetes and hypertension. The study aimed to evaluate the antihyperlipidemic effect of CP ethanol extract, as well as its inhibitory activity on apolipoproteinB48 (apoB48), in normal and hyperlipidemic mice. The antihyperlipidemic effect of CP was evaluated in hyperlipidemic mice induced by high-fat diet for 4 weeks. CP ethanol extract (0.37, 0.75 and 1.5g/kg/day) was orally administrated once daily. Lipids and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), together with the indices of hepatic and renal functions were examined. RT-qPCR and western blotting were used to analysis the expression levels of tumor necrosis factor (TNF-α), total- and triglyceride-rich apoB48 (TRL-apoB48), as well as the phosphorylation of the mitogen-activatein kinase (MAPK). CP as well as simvastatin rema...Continue Reading

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Citations

Jul 24, 2015·Canadian Journal of Physiology and Pharmacology·Xiaoming YaoZhiqi Yin
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zi LinZhi-Qi Yin
May 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yang LiuXiangxiang Fu
Apr 23, 2020·Natural Product Research·Hui-Hui SunKang-Ping Xu
May 26, 2017·Annals of the New York Academy of Sciences·Qiqiong LiMing-Yong Xie
Nov 7, 2017·Phytochemistry·Yan-Jiao ChenWei Wang
Apr 21, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhanwei YangWenjun Wang
May 27, 2021·Natural Product Research·Huihui SunKangping Xu
Mar 5, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mustapha TacherfioutBachra Khettal

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