Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats

Asian Pacific Journal of Tropical Medicine
Chinnadurai VeeramaniKodukkur Viswanathan Pugalendi

Abstract

To investigate the antihyperlipidemic effect of crude ethanolic extract of Melothria maderaspatana (M. maderaspatana) leaf (CEEM) on deoxycorticosterone acetate (DOCA)-salt hypertensive rats. A midscapular incision was made on each rat and the left kidney was excised after ligation of the renal artery. The surgical wound was closed using an absorbable suture. After one week recovery period, hypertension was induced by subcutaneous injection of DOCA-salt solution, twice a week, and the rats received a 1% sodium chloride solution as drinking water throughout the experimental period. CEEM or nifedipine was administered orally once a day for 6 weeks. In DOCA-salt hypertensive rats, the level of plasma and tissues of total cholesterol (TC), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) significantly increased and administration of CEEM significantly reduced these parameters towards normality. Further, the levels of low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) significantly increased while high density lipoprotein-cholesterol (HDL-C) decreased in hypertensive rats and administration of CEEM brought these parameters to normality which proved their antihyperlipide...Continue Reading

References

Jun 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·K FalholtW Falholt
Nov 1, 1981·Atherosclerosis·J P MalaspinaG Le Calve
Jun 23, 2001·Journal of Tropical Pediatrics·M A El-Hazmi, A S Warsy
Feb 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y R SailajaD Saralakumari
Nov 28, 2006·The European Journal of General Practice·José M TurónUNKNOWN Redimer Study Group Semfyc
Mar 9, 2007·Mymensingh Medical Journal : MMJ·D SarkarF Wahed
Oct 30, 2007·Journal of the American College of Cardiology·James O MuddPeter O Kwiterovich
Aug 9, 2008·Disease Markers·Huiling HuangYugang Dong
Aug 13, 2008·Hypertension·Giacomo D SimonettiMarkus G Mohaupt
Sep 2, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Schohraya SpahisEmile Levy
Mar 11, 2010·Journal of Hypertension·Atushi NakanoTatsuya Sawamura
May 12, 2010·Clinical and Experimental Pharmacology & Physiology·Pei WangChao-Yu Miao
May 29, 2010·Journal of Basic and Clinical Physiology and Pharmacology·Chinnadurai VeeramaniKodukkur Viswanathan Pugalendi
Jan 25, 2011·Lipids in Health and Disease·Tatyana P NovgorodtsevaNatalia V Zhukova

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.