Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative pain

Anesthesia and Analgesia
Masafumi KimuraShigeru Saito

Abstract

Tramadol is used to treat a wide range of acute and chronic pain. This drug induces analgesia by 2 mechanisms of action: opioid receptor activation and enhancement of noradrenaline (NA) and serotonin (5-HT) transmission. The effect of tramadol on NA and 5-HT concentrations in the spinal cord, however, have not been assessed. In the present study, we investigated the antihypersensitivity effect of tramadol using a rat model of postoperative pain. We also evaluated the increase in NA and 5-HT levels in the spinal cord after tramadol injection using in vivo microdialysis. We made a hindpaw incision in male Sprague-Dawley rats (postoperative pain model). Tramadol was administered intraperitoneally and intrathecally 24 hours after paw incision. Mechanical hypersensitivity was measured by determining the withdrawal threshold using von Frey filaments. Microdialysis studies from the dorsal horn of the lumbar spinal cord were performed to measure NA and 5-HT levels after intraperitoneal injection of tramadol. We also measured the NA and 5-HT content in the spinal cord in normal rats and rats with paw incision. Intraperitoneal (10, 20, and 40 mg/kg) and intrathecal (125, 250, and 500 μg) injection of tramadol produced an antihyperalgesic...Continue Reading

References

Jul 2, 1987·European Journal of Pharmacology·K H Carlsson, I Jurna
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Mar 1, 1996·Pain·T J BrennanG F Gebhart
Jan 1, 1997·European Journal of Clinical Pharmacology·W D PaarH J Dengler
Apr 27, 2001·Anesthesia and Analgesia·J L De WitteT Deloof
May 30, 2002·Progress in Neurobiology·Mark J Millan
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy
Feb 28, 2004·Brain : a Journal of Neurology·Renato GrassoFrancesco Lacquaniti
May 25, 2005·Basic & Clinical Pharmacology & Toxicology·Søren H SindrupTroels S Jensen
Jun 24, 2006·Neuropharmacology·Soichiro IdeKazutaka Ikeda
Mar 5, 2008·Journal of Clinical Pharmacy and Therapeutics·R B Raffa
Oct 7, 2009·The American Journal of Medicine·Alec B O'Connor, Robert H Dworkin
Jan 19, 2010·Pharmacological Reports : PR·Wojciech Leppert

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Citations

Aug 22, 2013·International Journal of Obstetric Anesthesia·A SubediK Pokharel
Oct 16, 2013·Peptides·Richard J Bodnar
Nov 8, 2015·The Journal of Pain : Official Journal of the American Pain Society·Vipin AroraChristopher M Peters
Apr 7, 2015·Revista brasileira de anestesiologia·Angela Maria Sousa, Hazem Adel Ashmawi
May 1, 2015·Brazilian Journal of Anesthesiology·Angela Maria Sousa, Hazem Adel Ashmawi
Jun 14, 2016·The Journal of Pharmacy and Pharmacology·Elizabeth Romero-AlejoAsunción Romero
Jun 3, 2014·Anesthesiology·Kelly Byrne, Ban Tsui
Aug 22, 2015·European Journal of Anaesthesiology·Mariana AbreuIgnacio A Gómez de Segura
Jan 10, 2019·Acta Cirúrgica Brasileira·Rosa Helena de Figueiredo ChavesAna Rita de Lima
Aug 19, 2017·BioMed Research International·Juliana Zampoli Boava PapiniGiovana Radomille Tofoli

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