Antihypertensive agents and the risk of breast cancer in women aged 55 years and older: a nested case-control study

Journal of Hypertension
Chia-Hsuin ChangMei-Shu Lai

Abstract

The study aimed to investigate the association of long-term use of different antihypertensive agents with incident breast cancer. A total of 794 ,533 women aged at least 55 years were identified from Taiwan National Health Insurance claims database during 2001-2011. As of 31 December 2011, incident breast cancer patients were included as cases, and 1 : 4 age-matched controls were selected by risk-set sampling scheme. Logistic regression models were applied to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer incidence associated with different durations of use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β-blockers, and dihydropyridine calcium channel blockers (DHP CCBs). Different restriction rules were applied to reveal the potential effects of confounding by indication. Among the 9397 incident breast cancer patients and 37 ,588 controls, a significantly elevated risk was found for relatively short-term use of DHP CCBs (<6 years) but not in those observed for more than 6 years. There was no association between either angiotensin-converting enzyme inhibitors/angiotensin receptor blockers or β-blockers use and breast cancer. Although restricting our analyses to thos...Continue Reading

References

Feb 22, 1997·Lancet·H JickC R Meier
Apr 9, 1998·Journal of Hypertension·D J HoleA F Lever
Apr 9, 1998·JAMA : the Journal of the American Medical Association·L RosenbergS Shapiro
Feb 11, 2000·Archives of Internal Medicine·C R MeierH Jick
Jul 24, 2001·European Heart Journal·E GrossmanU Goldbourt
Oct 26, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D C Felmeden, G Y Lip
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Jun 23, 2006·Breast Cancer Research and Treatment·Jon P FryzekSøren Friis
May 10, 2007·European Journal of Epidemiology·Scott Davis, Dana K Mirick
Feb 24, 2010·Diabetologia·S Hernández-Díaz, H-O Adami
Jun 8, 2010·Cancer Causes & Control : CCC·Joan A LargentHoda Anton-Culver
Aug 26, 2010·JAMA : the Journal of the American Medical Association·Bruce M Psaty, David S Siscovick
Oct 25, 2012·Diabetes Care·Katherine EspositoDario Giugliano
Mar 19, 2013·Cancer Causes & Control : CCC·Hye-Mi NohYoon-Ho Choi
Apr 11, 2013·Menopause : the Journal of the North American Menopause Society·Katherine EspositoDario Giugliano
May 8, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gitte Vrelits SørensenThomas P Ahern
Jul 9, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jean A McDougallChristopher I Li
Aug 6, 2013·Cancer Biomarkers : Section a of Disease Markers·Elias I Obeid, Suzanne D Conzen
Aug 8, 2013·JAMA Internal Medicine·Patricia F Coogan
Aug 8, 2013·JAMA Internal Medicine·Christopher I LiKathleen E Malone
Aug 21, 2013·Diabetes Care·Lamiae Grimaldi-BensoudaUNKNOWN ISICA Group
Jun 22, 2014·Endocrine-related Cancer·Keely M McNamaraWayne D Tilley

❮ Previous
Next ❯

Citations

Mar 21, 2017·Scientific Reports·Hedong HanJia He
Jun 29, 2017·Journal of Hypertension·Yi YangPierre-Antoine Dugué
Apr 16, 2018·Journal of Clinical Pharmacy and Therapeutics·A A ThakurR A Forse
Dec 28, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Valentina GuercioAlessandra Tavani
Jan 10, 2019·Journal of Hypertension·Vasiliki KatsiDimitrios Tousoulis
Jun 13, 2020·American Journal of Hypertension·Elias SanidasJohn Barbetseas
Feb 24, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Guoqiao ZhengJianguang Ji

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

SAS

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Chia-Hsuin ChangK Arnold Chan
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Jen-Chieh Lin, Mei-Shu Lai
© 2021 Meta ULC. All rights reserved