Antihypertensive and antioxidant action of amlodipine and vitamin C in patients of essential hypertension

Journal of Clinical Biochemistry and Nutrition
Aarti S MahajanPrakash C Ray

Abstract

The etiology of essential hypertension includes increased oxidative stress. The role of antihypertensive drug amlodipine as an antioxidant and the benefit of addition of vitamin C, an antioxidant to antihypertensive therapy were studied. Forty male patients of essential hypertension were randomly divided into two groups and treated with 5 mg amlodipine. In addition one group also received 1000 mg vitamin C (as two 500 mg tablets) once daily for three months. Although blood pressure decreased in both groups, the systolic blood pressure in patients given vitamin C was less (126.4 +/- 7.47) compared to the other group (130.9 +/- 7.27). A decrease in malondialdehyde, an increase in erythrocyte sodium-potassium adenosine triphosphatase (Na(+) K(+) ATPase) and an increase in the superoxide dismutase levels were observed in both groups. The increase in SOD was statistically more in the patients given vitamin C in addition to amlodipine (0.1717 +/- 0.0150 compared to 0.152 +/- 0.0219 units/100 ml assay). In spite of the known antihypertensive, antioxidant activity, similarity in correcting endothelial dysfunction independently, giving the two drugs together and early introduction of vitamin C perhaps decreases oxidative stress and augm...Continue Reading

References

Apr 1, 1976·Biochemical Medicine·K Yagi
Jan 1, 1992·Free Radical Biology & Medicine·F T van AmsterdamF Ursini
Jan 1, 1991·The American Journal of Clinical Nutrition·D L Trout
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Sep 1, 1987·Hypertension·D RygielskiA Aviv
Nov 1, 1988·The American Journal of Clinical Nutrition·J T SalonenR Rauramaa
Jan 1, 1995·Annual Review of Biochemistry·I Fridovich
Jan 1, 1993·Free Radical Research Communications·K V Kumar, U N Das
Apr 1, 1997·Clinical Science·H F GalleyN R Webster
Jan 15, 2000·Lancet·S J DuffyJ A Vita
Apr 19, 2000·Lancet·J B KostisC R Lacy
Jun 23, 2000·Annals of the New York Academy of Sciences·I T MakW B Weglicki
Jul 20, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·D MantleV R Preedy
Aug 5, 2000·Free Radical Biology & Medicine·J M May
Apr 17, 2001·BMJ : British Medical Journal·G BeeversE O'Brien
Apr 27, 2002·Annals of the New York Academy of Sciences·Gladys Block
Aug 8, 2002·The Korean Journal of Internal Medicine·Young Keun OnYun Shik Choi
Dec 7, 2002·Hypertension·Mi Kyung KimShoichiro Tsugane
Apr 23, 2003·Hypertension·Josep RedónGuillermo T Sáez
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Sep 15, 2004·American Journal of Hypertension·Agaba A GanafaMohamed A Bayorh
Sep 15, 2004·American Journal of Hypertension·Bernard Lassègue, Kathy K Griendling
Nov 9, 2004·Acta Cardiologica·Işil MutafAyşegül Uysal
Jun 16, 2005·American Journal of Nephrology·R Davis ManningShumei Meng

❮ Previous
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Citations

Feb 23, 2013·Current Hypertension Reports·Arrigo F G Cicero, Claudio Borghi
Sep 13, 2015·Annals of Medicine·Cesare R SirtoriArrigo F G Cicero
Sep 13, 2015·Vascular Pharmacology·Francesca SantilliGiovanni Davì
Oct 15, 2013·The Journal of Clinical Hypertension·Mark Houston
May 26, 2017·Food & Function·Arrigo F G CiceroAlessandro Colletti
Apr 3, 2019·International Journal of Molecular Sciences·Antonella FiordelisiDaniela Sorriento
Jan 24, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Arrigo F G CiceroClaudio Ferri
Jun 10, 2010·Expert Review of Cardiovascular Therapy·Mark C Houston
Jun 28, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Boris HanselAnatol Kontush
Jun 12, 2020·European Journal of Applied Physiology·Nattha MuangritdechApiwan Manimmanakorn
Feb 6, 2020·Experimental and Therapeutic Medicine·Toshiaki Matsutomo
Apr 12, 2012·The American Journal of Clinical Nutrition·Stephen P JuraschekEdgar R Miller
Mar 20, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Arrigo F G Cicero, Alessandro Colletti
Apr 6, 2018·Frontiers in Physiology·Daniela SorrientoGuido Iaccarino
Aug 10, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michael LauAlfonso E Garcia-Bennett
Jan 21, 2020·Food Research International·Samad Ghaffari, Neda Roshanravan

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Methods Mentioned

BETA
X-ray
MDA

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