PMID: 3521208Jan 1, 1986Paper

Antihypertensive and biochemical effects of different doses of hydrochlorothiazide alone or in combination with triamterene

Acta Medica Scandinavica
A KohvakkaA Eisalo

Abstract

The antihypertensive and biochemical effects of 25 mg hydrochlorothiazide alone or 50 mg hydrochlorothiazide alone or in combination with triamterene (either 37.5 or 75 mg) once daily were studied in 26 patients with essential hypertension. After a 5-week run-in period the patients were randomized to receive active therapy in a cross-over manner. Each treatment period lasted 3 months. All drugs significantly (p less than 0.01) lowered both systolic and diastolic blood pressure. There were no differences in blood pressure between the medication periods. Serum potassium concentration was slightly lower during all medication periods than during the run-in period. This change was statistically significant (p less than 0.01) only on 50 mg hydrochlorothiazide daily. There were no significant changes in serum magnesium during any of the periods compared to the run-in period. The lowest values were recorded on 50 mg hydrochlorothiazide alone and the highest on 50 mg hydrochlorothiazide plus 75 mg triamterene daily. A slight increase in serum urate was recorded in all medication periods compared to the run-in period. No significant changes were observed in serum total cholesterol, HDL cholesterol or triglycerides between any of the peri...Continue Reading

References

Jan 1, 1979·Acta Medica Scandinavica·A KohvakkaV Manninen
May 31, 1978·European Journal of Clinical Pharmacology·B Beermann, M Groschinsky-grind
Sep 1, 1966·Circulation·R E SpiekermanW F McGuckin
May 1, 1970·European Journal of Pharmacology·J P Guignard, G Peters

Citations

Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·M G ZieglerV Solt-Buzsaki
Jan 5, 2006·British Journal of Clinical Pharmacology·J A ClaytonI P Hall
Jan 1, 1993·Cardiovascular Drugs and Therapy·P Baumgart
Dec 17, 2009·Cardiology in Review·Kimberly M Neff, James J Nawarskas
Aug 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacob Atsmon, Eran Dolev
Nov 1, 1989·The Journal of International Medical Research·H JørgensenL E Peterson
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·B D RoyM Burnett
Jan 1, 1987·Fundamental & Clinical Pharmacology·M LabeeuwJ Sassard

Related Concepts

Blood Glucose
Clinical Trials
Dose-Response Relationship, Drug
Polychemotherapy
Electrolytes
Sectrazide
Hypertensive Disease
Lipids
Randomization
Urocaudal

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