PMID: 7025258Sep 5, 1981Paper

Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
W P Leary, A J Reyes

Abstract

A combination of hydrochlorothiazide 50 mg and amiloride 5 mg (HTZ + AMl) was administered twice daily for 12 weeks to 18 hypertensive patients, as a monotherapy. There was a statistically and clinically significant decrease in the mean blood pressure level throughout the treatment period. Significant steady or random changes in blood variables included decreases in chloride, magnesium and bilirubin levels and increases in sodium, calcium, phosphorus, creatinine, triglycerides, total protein, albumin, alkaline phosphatase and SGPT levels, Blood urea nitrogen values changed biphasically. Most of these statistically significant metabolic changes had no clinical relevance. The dosage problem with HTZ + AMl is discussed.

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.