PMID: 937076Jan 1, 1976

Antihypertensive effect and side-effects of bendroflumethiazide and propranolol

Acta Medica Scandinavica
G BerglundL Wilhelmsen

Abstract

The antihypertensive effect and side-effects during 12 months' treatment with bendroflumethiazide and propranolol have been compared in two randomly selected, equally large groups (n= 53) of previously untreated male hypertensives. Systolic BP above 170 or diastolic BP above 105 mmHg on two occasions were defined as hypertension. The same BP reduction was achieved in both groups. During the 12 months' treatment one subject on bendroflumethiazide developed diabetes mellitus and one on propranolol developed cardiac decompensation. None developed gout. Contrary to what had been presumed, glucose tolerance improved during 12 months' treatment with both agents, while there were no changes in fasting blood sugar, insulin or triglyceride concentrations. No changes were found in serum potassium or total body potassium during 12 months' bendroflumethiazide treatment, while serum potassium increased during treatment with propranolol. Uric acid increased slightly during treatment with both agents. Prolongation of the follow-up to 24 months did not change any of the findings regarding metabolic changes during treatment. The frequency of subjective side-effects decreased to the same extent during treatment with both drugs. It is concluded t...Continue Reading

References

Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·A M Michelakis, R G McAllister
Mar 1, 1972·Preventive Medicine·L WilhelmsenL Werkö
May 1, 1973·Acta Medica Scandinavica·B DegnbolT Marner
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Citations

Jan 1, 1979·Acta Medica Scandinavica. Supplementum·C Bengtsson
Nov 27, 1978·European Journal of Clinical Pharmacology·A P Douglas-JonesA Lee
Mar 1, 1984·Klinische Wochenschrift·W KroneH Greten
Dec 1, 1983·British Journal of Clinical Pharmacology·A MarkelM B Youdim
Jan 1, 1989·European Journal of Clinical Pharmacology·N A MintonJ A Henry
Sep 1, 1983·Hypertension·P WeidmannR Mordasini
Jan 1, 1985·Acta Medica Scandinavica·G S Andersen
Jan 1, 1976·Acta Medica Scandinavica·G BerglundL Wilhelmsen
Jan 1, 1981·European Journal of Clinical Pharmacology·O AnderssonJ Thomis
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·C Bengtsson
Jan 1, 1980·The Journal of International Medical Research·L R Solomon, P M Dawes
Jan 1, 1982·Biopharmaceutics & Drug Disposition·M KramlJ Mullane
Jan 1, 1982·Acta Medica Scandinavica·H J JürgensenO Faergeman
May 26, 2007·Clinical Drug Investigation·Galina PassareJohan Fastbom

Related Concepts

Esberizid
Blood Glucose
Diastolic Blood Pressure
Pulse Rate
Hypertensive Disease
Novolin
Potassium
Rexigen
Triglycerides
Urate

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