Antihypertensive Effect of γ-Aminobutyric Acid-Enriched Brown Rice on Spontaneously Hypertensive Rats

Journal of Nutritional Science and Vitaminology
Kohei KawakamiMasato Nomura

Abstract

'Haiibuki' is a giant embryo rice cultivar that contains abundant γ-aminobutyric acid (GABA) compared with conventional rice cultivars. Here, we performed a functional evaluation of 'GABA-enriched brown rice' (GEBR) prepared by modifying the 'Haiibuki' cultivar to contain more GABA. Study 1: Spontaneously hypertensive rats were divided into three groups [control (cornstarch), normal brown rice, and GEBR] and fed an orally administered diet for 4 wk. A significant blood pressure elevation-inhibitory effect was observed in the GEBR group as compared with the other groups. Study 2: Rats were divided into two groups and fed ad libitum for 12 wk. The two groups were control (commercial feed with 5% cornstarch) and GEBR (commercial feed with 5% GEBR). Body weight, blood pressure, food consumption, and water intake were measured during the study period, and blood chemistry was analyzed after the study. Plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) and urinary isoprostane were measured 12 and 10 wk after the start of the study, respectively. A significant blood pressure elevation-inhibitory effect was observed in the GEBR group. The 8-OHdG and isoprostane levels were significantly lower in the GEBR group than in the control group, demons...Continue Reading

References

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Citations

Aug 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Cong HanZhen-Qiang Qi
Jul 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dai-Hung Ngo, Thanh Sang Vo
Nov 17, 2020·Critical Reviews in Food Science and Nutrition·Michio HashimotoKatsumi Yoshino
Nov 5, 2020·Neurochemistry International·Tina Hinton, Graham A R Johnston

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