Antihypertensive effect of a non-selective (propranolol) and a cardioselective (metoprolol) beta-adrenoceptor blocking agent at rest and during exercise

British Journal of Clinical Pharmacology
N ClausenK Mellemgaard


1 The antihypertensive effects at rest and during physical exercise of the non-selective beta-adrenoceptor blocker propranolol and the cardioselective beta-adrenoceptor blocker metoprolol were compared in a double-blind cross-over study. 2 Eighteen patients with mild hypertension entered the trial. One patient was withdrawn from the study due to side effects on both drugs. 3 The two beta-adrenoceptor blockers were compared using doses earlier shown to have the same beta-adrenoceptor blocking potency, as measured by their effect on exercise tachycardia in healthy men. 4 Arterial blood pressure was reduced to the same extent by propranolol and metoprolol at rest as well as during submaximal work. 5 It is concluded that the antihypertensive effect of beta-adrenoceptor blockers is mainly mediated through blockade of the beta 1-adrenoceptors.


May 17, 1975·British Medical Journal·L HanssonA Westerlund
Mar 22, 1976·European Journal of Clinical Pharmacology·L HanssonB E Karlberg
Oct 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·H H Parving, F Gyntelberg
May 1, 1973·British Heart Journal·P A MajidS H Taylor

Related Concepts

Antihypertensive Agents
Diastolic Blood Pressure
Clinical Trials
Double-Blind Method
Cardiopulmonary Exercise Test
Hypertensive Disease
Patient Non-Compliance

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