Antihypertensive effect of radix paeoniae alba in spontaneously hypertensive rats and excessive alcohol intake and high fat diet induced hypertensive rats

Evidence-based Complementary and Alternative Medicine : ECAM
Chen Su-HongLv Gui-Yuan

Abstract

Radix Paeoniae Alba (Baishao, RPA) has long been used in traditional Chinese medicine formulation to treat hypertension by repression the hyperfunction of liver. However, whether the RPA itself has the antihypertensive effect or not is seldom studied. This study was to evaluate the protective effect of RPA on hypertensive rats. Alcohol in conjunction with a high fat diet- (ACHFD-) induced hypertensive rats and spontaneously hypertensive rats (SHR) was constantly received either RPA extract (25 or 75 mg/kg) or captopril (15 mg/kg) all along the experiments. As a result, RPA extract (75 mg/kg) could significantly reduce systolic blood pressure of both ACHFD-induced hypertensive rats and SHR after 9-week or 4-week treatment. In ACHFD-induced hypertensive rats, the blood pressure was significantly increased and the lipid profiles in serum including triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly deteriorated. Also, hepatic damage was manifested by a significant increase in alanine transaminase (ALT) and aspartate transaminase (AST) in serum. The RPA extract significantly reversed these parameters, which revealed that it could alleviate the liver damage of rats. In SHR, our result suggested t...Continue Reading

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Citations

May 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haein KimOran Kwon
Feb 12, 2020·Journal of Complementary & Integrative Medicine·Charlotte Mungho TataBenedicta Ngwenchi Nkeh-Chungag
Mar 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Bo LiSu-Hong Chen
Mar 5, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Minxia PangGuiyuan Lv

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Methods Mentioned

BETA
ELISA

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SPSS

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