Abstract
We examined the effect of methanol/methylene chloride extract of Dorstenia psilurus given by gastric intubation on systolic blood pressure, plasma glucose, insulin, cholesterol, triglycerides and creatinine in rats with fructose-induced hypertension. Male Wistar rats in groups of 6 animals each were fed fructose-rich diets or standard chow for 3 weeks and treated with 100 mg/kg/day or 200 mg/kg/day of plant extract or vehicle for 3 subsequent weeks. Systolic blood pressure was measured every three days using the indirect tail cuff method. Systolic blood pressure was higher in fructose-fed rats (142+/-2 mm Hg, p < 0.01) compared with the controls (112+/-2 mm Hg), and was lower in Dorstenia psilurus-treated groups (127+/-2 and 119+/-1 mm Hg for the dose of 100 and 200 mg/kg, respectively) compared with the fructose-fed rats. Plasma insulin, cholesterol and triglycerides were higher on the fructose-rich diet compared with the controls. Plasma insulin and cholesterol were lower in the Dorstenia psilurus-treated groups. These results suggest that, Dorstenia psilurus treatment could prevent and reverse high blood pressure induced by a diet rich in fructose probably by improvement of plasma insulin levels. The plant extract might prov...Continue Reading
References
Jan 1, 1991·Memórias do Instituto Oswaldo Cruz·B M RuppeltN A Pereira
Nov 1, 1991·Hypertension·G M ReavenH Chang
Mar 1, 1991·Diabetes Care·R A DeFronzo, E Ferrannini
Nov 1, 1987·Hypertension·I S HwangG M Reaven
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Dec 1, 1994·Diabetes·M K LeeJ M Olefsky
Mar 1, 1994·Hypertension·S BhanotM Bryer-Ash
Jul 1, 1997·Journal of Cardiovascular Pharmacology·N SambandamB Rodrigues
Aug 1, 1997·Japanese Journal of Pharmacology·M SuzukiH Ikeda
Aug 27, 1998·Hypertension·T C Fang, W C Huang
Mar 9, 1999·Journal of Cardiovascular Pharmacology·A CosenziG Bellini
Citations
Nov 3, 2009·The British Journal of Nutrition·Hyun Young KimTakako Yokozawa
May 31, 2011·Journal of Asian Natural Products Research·Hidayat HussainKarsten Krohn
Jun 20, 2012·BMC Research Notes·Igor K VoukengJean-Marie Pages
Apr 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wannaporn SuwannaphetSirichai Adisakwattana
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Glen S PattenLouise E Bennett
Oct 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·O VargaA K Hansen
Feb 5, 2011·Journal of Ethnopharmacology·Victor KueteThomas Efferth
May 12, 2015·BioMed Research International·Victor Kuete, Thomas Efferth
Apr 18, 2015·Biological Research·Bruno Moukette MouketteJeanne Yonkeu Ngogang
Aug 24, 2005·Progress in Cardiovascular Diseases·Mark C Houston
Jul 1, 2020·Archives of Physiology and Biochemistry·Handan MertNihat Mert
Jun 20, 2017·Frontiers in Pharmacology·Armelle T MbavengThomas Efferth
Dec 9, 2008·Journal of Natural Products·Turibio K TabopdaMarie-Aleth Lacaille-Dubois