Antihypertensive effects of Dorstenia psilurus extract in fructose-fed hyperinsulinemic, hypertensive rats

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Théophile DimoT B Ngadjui

Abstract

We examined the effect of methanol/methylene chloride extract of Dorstenia psilurus given by gastric intubation on systolic blood pressure, plasma glucose, insulin, cholesterol, triglycerides and creatinine in rats with fructose-induced hypertension. Male Wistar rats in groups of 6 animals each were fed fructose-rich diets or standard chow for 3 weeks and treated with 100 mg/kg/day or 200 mg/kg/day of plant extract or vehicle for 3 subsequent weeks. Systolic blood pressure was measured every three days using the indirect tail cuff method. Systolic blood pressure was higher in fructose-fed rats (142+/-2 mm Hg, p < 0.01) compared with the controls (112+/-2 mm Hg), and was lower in Dorstenia psilurus-treated groups (127+/-2 and 119+/-1 mm Hg for the dose of 100 and 200 mg/kg, respectively) compared with the fructose-fed rats. Plasma insulin, cholesterol and triglycerides were higher on the fructose-rich diet compared with the controls. Plasma insulin and cholesterol were lower in the Dorstenia psilurus-treated groups. These results suggest that, Dorstenia psilurus treatment could prevent and reverse high blood pressure induced by a diet rich in fructose probably by improvement of plasma insulin levels. The plant extract might prov...Continue Reading

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Citations

May 31, 2011·Journal of Asian Natural Products Research·Hidayat HussainKarsten Krohn
Apr 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wannaporn SuwannaphetSirichai Adisakwattana
Oct 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·O VargaA K Hansen
Feb 5, 2011·Journal of Ethnopharmacology·Victor KueteThomas Efferth
May 12, 2015·BioMed Research International·Victor Kuete, Thomas Efferth
Dec 9, 2008·Journal of Natural Products·Turibio K TabopdaMarie-Aleth Lacaille-Dubois

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