Antihypertensive effects of mibefradil: a double-blind comparison with diltiazem CD

Clinical Cardiology
B M MassieI Korrin

Abstract

Mibefradil is the first compound of a new class of calcium antagonists with a unique chemical structure and mechanism of action. This trial compared mibefradil with diltiazem CD, a widely prescribed calcium antagonist for the treatment of hypertension. In all, 201 patients with uncomplicated, mild-to-moderate essential hypertension with a baseline sitting diastolic blood pressure (SDBP) of > or = 95 and < or = 114 mmHg were evenly randomized to receive either mibefradil (100 mg) or diltiazem CD (360 mg) daily for 12 weeks. To determine whether antihypertensive effects persisted after 12 weeks, patients then entered a 4-week withdrawal period during which they remained on active treatment or were switched to placebo. Efficacy variables were the changes from baseline in SDBP to the end of the treatment period (Week 12) and during the randomized withdrawal period (Week 16). At Week 12, the reduction from baseline in SDBP at trough was significantly greater (p < 0.001) in the mibefradil group (-14.0 +/- 7.8 mmHg) than in the diltiazem CD group (-9.5 +/- 7.5 mmHg). Significantly more patients (72%) on mibefradil achieved SDBP normalization by Week 12 than did patients on diltiazem (51%) (p < 0.01). Patients maintained on mibefradil ...Continue Reading

References

Sep 1, 1992·Clinical Pharmacology and Therapeutics·R SchmittH A Welker
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Jul 1, 1994·Circulation Research·S K Mishra, K Hermsmeyer
Nov 7, 1996·The American Journal of Cardiology·A M Katz

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Citations

Jul 8, 2003·Current Hypertension Reports·George S Chrysant, Steven G Chrysant
Dec 31, 1997·The American Journal of Cardiology·B M Massie
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·W H Frishman
Jun 26, 1998·The Annals of Pharmacotherapy·S J Billups, B L Carter
Mar 3, 1998·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·I Kobrin

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