PMID: 16520854Mar 8, 2006Paper

Antihypertensive medications and blood sugar: theories and implications

The Canadian Journal of Cardiology
David F Blackburn, Thomas W Wilson

Abstract

Increased rates of diabetes have been reported with thiazide diuretics and beta-blockers, but not with angiotensin-converting enzyme inhibitors, angiotensin receptor blockers or calcium channel blockers. These observations are important because significant glycemic effects of drugs may be a source of accelerated cardiovascular risk that is not detectable during restricted clinical trial follow-up periods. The extent to which diabetes is affected by these medications remains unclear, as is the precise mechanism by which diabetes is promoted. However, several plausible theories are presented herein. Although drug-induced diabetes has been a concern for several years, not enough information is available to influence prescribing for the majority of patients. The number one priority should be controlling blood pressure in a timely manner.

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Citations

May 31, 2006·Critical Care : the Official Journal of the Critical Care Forum·Philippe E R LheureuxAndrea Penaloza
Mar 21, 2013·Journal of the American Medical Directors Association·Martin Wehling
Jan 28, 2010·The American Journal of Cardiology·Jeffrey S Borer, Jean-Claude Tardif
Jan 1, 2013·Case Reports in Critical Care·Nadine MonteiroPedro Póvoa
Jun 10, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Bertrand N MuketeThierry H Le Jemtel
Jul 22, 2016·Journal of Pharmacology & Pharmacotherapeutics·Sandesh Madhukar Bharati, Nishith Singh
Oct 6, 2016·Diabetes·Rachael C AikensBenjamin F Voight
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Nov 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nida Siddiqi, Ibrahim F Shatat
Nov 13, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel M TremmelSara D Sackett
Jul 6, 2021·Journal of Diabetes and Metabolic Disorders·Tadeg Jemere, Belayneh Kefale

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