DOI: 10.1101/19001719Jul 8, 2019Paper

Antihypertensive medications as repurposed treatments for mood disorders: analysis of linked healthcare data for 1.8 million patients

MedRxiv : the Preprint Server for Health Sciences
Richard J ShawDaniel J Smith


Background: Recent work suggests that antihypertensive medications may be useful as repurposed treatments for mood disorders. Using large-scale linked healthcare data we investigated whether certain classes of antihypertensive, such as angiotensin antagonists and calcium channel blockers, were associated with reduced risk of new-onset Major Depressive Disorder (MDD) or bipolar disorder. Method: Two cohorts of patients treated with antihypertensives were identified from Scottish prescribing (2009-2016) and hospital admission (1981-2016) records. Eligibility for cohort membership was determined by receipt of a minimum of four prescriptions for antihypertensives within a 12-month window. One treatment cohort (n=538,730) included patients with no previous history of mood disorder, whereas the other (n=262,278) included those who did. Both cohorts were matched by age, sex and area deprivation to untreated comparators. Associations between antihypertensive treatment and new-onset MDD or bipolar episodes were investigated using Cox regression. Results: For patients without a history of mood disorder, antihypertensives were associated with increased risk of new-onset MDD. For angiotensin antagonist monotherapy, the hazard ratio (HR) fo...Continue Reading

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