Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease

The Journal of Clinical Hypertension
Oyunbileg MagvanjavJulie A Johnson

Abstract

We used electronic health records (EHRs) data from 5658 ambulatory chronic kidney disease (CKD) patients with hypertension and prescribed antihypertensive therapy to examine antihypertensive drug prescribing patterns, blood pressure (BP) control, and risk factors for resistant hypertension (RHTN) in a real-world setting. Two-thirds of CKD patients and three-fourths of those with proteinuria were prescribed guideline-recommended renoprotective agents including an angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin receptor blocker (ARB); however, one-third were not prescribed an ACEI or ARB. CKD patients, particularly those with stages 1-2 CKD, who were prescribed regimens including beta-blocker (BB) + diuretic or ACEI/ARB + BB + diuretic were more likely to have controlled BP (<140/90 mm Hg) compared to those prescribed other combinations. Risk factors for RHTN included African American race and major comorbidities. Clinicians may use these findings to tailor antihypertensive therapy to the needs of each patient, including providing CKD stage-specific treatment, and better identify CKD patients at risk of RHTN.

References

May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Dec 8, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul MuntnerUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Feb 13, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Matthew R Weir, Mark Rolfe
Mar 2, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gavin J Becker, David C Wheeler
Oct 6, 2010·Journal of General Internal Medicine·Adrienne S AllenThomas D Sequist
Jan 8, 2011·Kidney & Blood Pressure Research·Luca De NicolaRoberto Minutolo
Jul 26, 2012·The Australian Journal of Rural Health·Louis S J PilottoDavid R J Kennedy
Sep 7, 2012·Journal of the American Society of Hypertension : JASH·Rajiv Agarwal, Arjun D Sinha
Oct 12, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Anastasia G PtinopoulouAnastasios N Lasaridis
Apr 5, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Hari TalrejaBrendan B McCormick
Apr 30, 2013·Journal of the American College of Cardiology·Luca De NicolaRoberto Minutolo
Jun 27, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jicheng LvVlado Perkovic
Jul 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Rikki M TannerPaul Muntner
Sep 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yelena R Drexler, Andrew S Bomback
Dec 20, 2013·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Nynke D Scherpbier-de HaanWim J C de Grauw
Mar 10, 2015·Current Hypertension Reports·Arjun D Sinha, Rajiv Agarwal
Sep 4, 2015·Disease-a-month : DM·Richard GargiuloEdgar Lerma
Nov 5, 2015·Lancet·Patrick RossignolUNKNOWN Cardiovascular and Renal Clinical Trialists (F-CRIN INI-CRCT) network
Apr 14, 2016·Current Hypertension Reports·Martin J Wolley, Michael Stowasser
Nov 23, 2016·Advances in Experimental Medicine and Biology·Seyed Mehrdad Hamrahian, Bonita Falkner
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
May 4, 2017·Hypertension·Pankaj GuptaMaciej Tomaszewski
Oct 31, 2017·Current Cardiology Reports·Nomsa Musemwa, Crystal A Gadegbeku
Feb 27, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv SaranVahakn Shahinian

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Citations

Nov 15, 2018·The Journal of Clinical Hypertension·Paola Varleta, Rodrigo Tagle
Jan 31, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Jeffrey L AndersonBenjamin D Horne

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