Antihypertensive treatment and the responsiveness to glutamate in ventrolateral medulla

Hypertension
T TsuchihashiM Fujishima

Abstract

We have recently reported that the cardiovascular responses to excitatory amino acids are augmented in the rostral ventrolateral medulla of spontaneously hypertensive rats (SHR). In the present study, we investigated whether the responsiveness to excitatory amino acids would be normalized by antihypertensive treatment. Thus we treated 4-week-old SHR and age-matched Wistar-Kyoto (WKY) rats with either enalapril (25 mg/kg per day in drinking water) or vehicle for 8 weeks. At 12 weeks of age, systolic blood pressure in the untreated SHR (248+/-9 mm Hg) was significantly (P<.01) higher than that in the enalapril-treated SHR (140+/-4 mm Hg), untreated WKY rats (148+/-4 mm Hg), and enalapril-treated WKY rats (117+/-1 mm Hg). The pressor responses to L-glutamate (2 nmol) microinjected into the rostral ventrolateral medulla were similar in enalapril-treated and untreated SHR (40+/-5 and 47+/-3 mm Hg, respectively, NS), and these responses were significantly greater than that seen in the untreated WKY rats (24+/-2 mm Hg, P<.01). On the other hand, the pressor response to either N-methyl-D-aspartate, an ionotropic glutamate receptor agonist, or (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid, a metabotropic glutamate receptor agonist, ...Continue Reading

References

Aug 1, 1991·Journal of Hypertension·J Chalmers, P Pilowsky
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Jan 1, 1986·Journal of Cardiovascular Pharmacology·T UngerR E Lang
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Citations

Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick J Mueller
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yingzi LinMitsuo Iida
Jul 12, 2011·Pharmacology, Biochemistry, and Behavior·Krzysztof ŁukawskiStanisław J Czuczwar
May 20, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Yang-Kai WangWei-Zhong Wang
May 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas A MischelPatrick J Mueller
Apr 3, 2013·American Journal of Hypertension·Kanchan BhatiaJennifer C Sullivan
Jul 30, 2002·The Journal of Biological Chemistry·John B J KwokVimal Kapoor

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