PMID: 2481174Jan 1, 1987Paper

Antihypertensive treatment in elderly hypertensives: implications of the MEHP study.

Journal of Cardiovascular Pharmacology
J Wikstrand

Abstract

Present evidence from several secondary and primary preventive trials indicates that if antihypertensive treatment is initiated with a beta-blocker, a better preventive effect on total mortality, cardiovascular mortality, and atherosclerotic complications can be expected than if diuretics are used as initial therapy. Results from a recent large-scale multicenter international study (MEHP) have shown that a regimen initiating antihypertensive treatment with 100 mg metoprolol once daily is effective, safe, and well-tolerated in elderly hypertensive patients. This might be of particular importance since a steep increase in cardiovascular mortality and other atherosclerotic complications is seen with age.

Citations

Aug 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nicole H PurcellJeffery D Molkentin

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