PMID: 2499021Jan 1, 1989Paper

Antiidiotypic suppression of autoantibodies with normal polyspecific immunoglobulins

Research in Immunology
F RossiM D Kazatchkine

Abstract

A mechanism by which therapeutic normal polyspecific immunoglobulins (IVIg) may suppress autoimmune responses in vivo is that of antiidiotypic suppression of autoantibodies mediated by anti-idiotypes present in IVIg. In vitro incubation with IVIg of either the plasma or the IgG fraction from plasma of patients with autoantibodies against procoagulant factor VIII (VIII:C), DNA, thyroglobulin, peripheral nerve and intrinsic factor resulted in dose-dependent inhibition of autoantibody activity. The pattern of inhibition curves showed a prozone phenomenon. Maximal inhibition was achieved at a ratio of patient's IgG to IVIg which was specific for each antibody tested. Inhibition was dependent on idiotypic/antiidiotypic interactions between autoantibodies and IVIg since: 1) F(ab')2 from IVIg inhibited autoantibody activity in F(ab')2 fragments from patients' IgG; 2) IVIg contained no antigen-like activity and no antibodies against the commonest allotypes expressed in F(ab')2 fragments of human IgG; 3) autoantibody activity in F(ab')2 fragments from patients' IgG was specifically retained on affinity columns of Sepharose-bound F(ab')2 fragments from IVIg. The presence of antiidiotypes against autoantibodies in pooled normal IgG suppor...Continue Reading

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Citations

Jan 1, 1991·Annals of the New York Academy of Sciences·C K Kasper
Nov 1, 1989·Clinical Immunology and Immunopathology·U E NydeggerM D Kazatchkine
Mar 1, 1994·Annals of Emergency Medicine·D Sadowitz, T E Terndrup
Feb 20, 1999·The Diabetes Educator·B S FreelandD L Seal
Mar 1, 1996·European Journal of Immunology·A AyoubaA Coutinho
Mar 18, 2010·Nature Reviews. Nephrology·James Gloor, Mark D Stegall
Jan 1, 1989·International Reviews of Immunology·M D KazatchkineU Nydegger
Jan 9, 1992·The New England Journal of Medicine·J M Dwyer
Dec 12, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jochen H O Hoffmann, Alexander H Enk
Jun 28, 2019·Frontiers in Immunology·Jochen H O Hoffmann, Alexander H Enk
Jun 18, 2011·Current Opinion in Organ Transplantation·Peter D Hughes, Solomon J Cohney

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