PMID: 490552Sep 1, 1979Paper

Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid

Journal of Medicinal Chemistry
W J WelsteadL F Sancilio

Abstract

The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models.

Citations

Apr 1, 1993·Journal of Computer-aided Molecular Design·J RuizR Pouplana
Jun 1, 1982·Pharmacological Research Communications·T MatsumotoT Takano
May 1, 1984·Journal of Pharmaceutical Sciences·E Cullen
Nov 28, 2013·Organic & Biomolecular Chemistry·Christina T LollarAlexander R Lippert
Nov 22, 1996·Journal of Medicinal Chemistry·M H NormanG C Rigdon
Feb 24, 2012·Organic Letters·Yongju XieYuhong Zhang
May 23, 2014·Organic Letters·You ZiShun-Jun Ji

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