Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L

Phytotherapy Research : PTR
Supinya TewtrakulOrapun Yodsaoue

Abstract

Extracted compounds from Caesalpinia sappan L. were examined for the inhibitory activity against NO, PGE2 , and TNF-α productions and on associated transcription levels using RAW264.7 cells. They were also tested for their effects on wound healing using fibroblast L929 cells. Among the compounds tested, brazilin (8) was the most effective against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells with an IC50 value of 10.3 μM, followed by sappanchalcone (2, 31.0 μM). Brazilin (8) also inhibited PGE2 and TNF-α production with IC50 values of 12.6 and 87.2 μM, respectively. The antiinflammatory mechanism of brazilin involved down regulation of the mRNA expressions of the iNOS, COX-2, and TNF-α genes in a dose-dependent manner. An ethanol (EtOH) extract of C. sappan significantly increased fibroblast proliferation, fibroblast migration, and collagen production, whereas brazilin (8) only stimulated fibroblast migration. In addition, the EtOH extract showed no acute toxicity in mice, and it was therefore safe to make use of its potent antiinflammatory and wound healing activities. Brazilin was mainly responsible for its antiinflammatory effect through its ability to inhibit the production of NO, PGE2 , and TNF-α. This s...Continue Reading

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Citations

Aug 4, 2016·Journal of Ethnopharmacology·David Raj ChellappanPemiah Brindha
Aug 17, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Talita Dacroce ToninJosé Roberto Santin
Feb 16, 2017·Phytotherapy Research : PTR·Urmimala DasKrishna Pramanik
May 4, 2018·Phytotherapy Research : PTR·Janaína Artem AtaidePriscila Gava Mazzola
Aug 16, 2018·Phytotherapy Research : PTR·Pattreeya TungcharoenSupinya Tewtrakul
Mar 5, 2016·PloS One·Fernanda Giacomini BuenoJoão Carlos Palazzo de Mello
Nov 23, 2019·Phytotherapy Research : PTR·Pattreeya TungcharoenSupinya Tewtrakul
Apr 16, 2020·Organic & Biomolecular Chemistry·Emerson E F Dos SantosAirton G Salles
Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Aleksandra ShedoevaChen Fan
Dec 3, 2016·BMC Complementary and Alternative Medicine·Adisak WongkajornsilpKittipong Maneechotesuwan
May 13, 2017·Inflammation·Zhan-Yuan LiHan-Yang Ye

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