Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells

The Journal of Endocrinology
Linda VignozziMario Maggi

Abstract

Progression of benign prostatic hyperplasia (BPH) involves chronic inflammation and immune dysregulation. Preclinical studies have demonstrated that prostate inflammation and tissue remodeling are exacerbated by hypogonadism and prevented by testosterone supplementation. We now investigated whether, in humans, hypogonadism was associated with more severe BPH inflammation and the in vitro effect of the selective androgen receptor agonist dihydrotestosterone (DHT) on cultures of stromal cells derived from BPH patients (hBPH). Histological analysis of inflammatory infiltrates in prostatectomy specimens from a cohort of BPH patients and correlation with serum testosterone level was performed. Even after adjusting for confounding factors, hypogonadism was associated with a fivefold increased risk of intraprostatic inflammation, which was also more severe than that observed in eugonadal BPH patients. Triggering hBPH cells by inflammatory stimuli (tumor necrosis factor α, lipopolysaccharide, or CD4(+)T cells) induced abundant secretion of inflammatory/growth factors (interleukin 6 (IL6), IL8, and basic fibroblast growth factor (bFGF)). Co-culture of CD4(+)T cells with hBPH cells induced secretion of Th1 inducer (IL12), Th1-recruiting ...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·W BartschK D Voigt
Jan 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J T IsaacsP C Walsh
Feb 15, 2001·The Journal of Urology·R KozlowskiK M Azadzoi
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Georg E SteinerMichael Marberger
Dec 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Giuseppe Danilo NorataAlberico Luigi Catapano
Dec 22, 2006·European Urology·Gero KramerMichael Marberger
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
May 4, 2007·Endocrine Reviews·Mario RotondiPaola Romagnani
Sep 8, 2007·BJU International·Claus G RoehrbornUNKNOWN BPH Registry and Patient Survey Steering Committee
Apr 12, 2008·The American Journal of Pathology·Maryla KrajewskaStan Krajewski
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
Apr 15, 2010·The Journal of Sexual Medicine·Jacques BuvatMichael Zitzmann
Dec 22, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kazuyoshi ShigeharaMikio Namiki
Jun 15, 2011·Differentiation; Research in Biological Diversity·Isaiah G Schauer, David R Rowley

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Citations

Apr 4, 2013·The Journal of Endocrinology·Daniel M Kelly, T Hugh Jones
Jan 11, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hertzel SalmanHanna Bessler
Jan 25, 2014·Journal of Endocrinological Investigation·L VignozziM Maggi
Nov 26, 2015·Clinical Investigation·Kouji IzumiChawnshang Chang
Jul 28, 2013·Current Bladder Dysfunction Reports·M GacciM Carini
Jan 13, 2016·Nature Reviews. Urology·Linda VignozziMario Maggi
Dec 2, 2015·World Journal of Urology·Giorgio Ivan RussoGiuseppe Morgia
Jul 15, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Giorgio Ivan RussoGiuseppe Morgia
Jun 17, 2015·Current Urology Reports·Aaron MooreTobias S Köhler
Mar 18, 2015·Journal of Endocrinological Investigation·C-H ChouC-H Kao
Mar 10, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Hailin RenXi Za
Sep 25, 2014·Asian Journal of Andrology·Farid Saad
Mar 27, 2015·International Journal of Environmental Research and Public Health·Aleksandra RyłMaria Laszczyńska
May 16, 2014·American Journal of Reproductive Immunology : AJRI·Leonardo Oiveira MendesFrancisco Eduardo Martinez
Jul 22, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Giorgio I RussoGiuseppe Morgia
Jan 19, 2018·Cell Biology International·Cristiano Pedrozo VieiraEdson Rosa Pimentel
Apr 6, 2018·Endocrine-related Cancer·B CioniA M Bergman
Sep 18, 2013·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Apr 14, 2016·Nature Communications·Meng-Lei ZhuMaureen A Su
Oct 1, 2016·Nature Reviews. Urology·Cosimo De NunzioAndrea Tubaro
Sep 25, 2019·International Journal of Molecular Sciences·Naoko KandaHidehisa Saeki
Feb 15, 2020·Andrology·Eduardo P Miranda, Luiz Otávio Torres
Jul 31, 2020·Physiological Reviews·Arianna GiacominiMarco Presta

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