Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances

World Journal of Microbiology & Biotechnology
Adriana M do NascimentoAndréa M do Nascimento

Abstract

The purpose of this work was to evaluate the antileishmanial activity of endophytic fungi isolated from leaves of Vernonia polyanthes plant and their prospective use in the discovery of bioactive compounds. Sixteen endophytes were isolated by using potato dextrose agar medium and submitted to cultivation in rice medium. The fungal cultures were extracted with ethanol and used as crude extracts for testing their antileishmanial activity. The most active ethanol extract was obtained from P2-F3 strain, which was identified as Cochliobolus sativus by ITS rRNA gene sequence data. Followed by a bioassay-guided fractionation, the cochlioquinone A, isocochlioquinone A and anhydrocochlioquinone A compounds were isolated from the crude extracts and demonstrated to inhibit the parasites. From the present work, it is possible to conclude that endophytic fungi derived from medicinal plant V. polyanthes may be considered promising source for the discovery of bioactive compounds.

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Citations

Jul 25, 2017·Journal of Basic Microbiology·Aiyatullah ShahAehtesham Hussain
Apr 6, 2019·Metabolomics : Official Journal of the Metabolomic Society·Lucas A ChibliFernando B Da Costa
Sep 30, 2019·Natural Products and Bioprospecting·Rufin Marie Kouipou Toghueo
Aug 8, 2020·Frontiers in Cellular and Infection Microbiology·Danielle de Sousa LopesJane Lima-Santos
Apr 24, 2019·World Journal of Microbiology & Biotechnology·Louis BengyellaPranab Roy
Jan 8, 2021·Parasitology Research·Jean Baptiste Hzounda FokouFabrice Fekam Boyom
Jun 25, 2020·Mini Reviews in Medicinal Chemistry·Maria Beatriz Silva Costa, Camila Martins de Oliveira
Jul 15, 2021·Natural Products and Bioprospecting·Patrick O SakyiSamuel K Kwofie

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