Antileishmanial and cytotoxic effects of essential oil and methanolic extract of Myrtus communis L

The Korean Journal of Parasitology
Hossein MahmoudvandEbrahim Saedi Dezaki

Abstract

Plants used for traditional medicine contain a wide range of substances that can be used to treat various diseases such as infectious diseases. The present study was designed to evaluate the antileishmanial effects of the essential oil and methanolic extract of Myrtus communis against Leishmania tropica on an in vitro model. Antileishmanial effects of essential oil and methanolic extract of M. communis on promastigote forms and their cytotoxic activities against J774 cells were evaluated using MTT assay for 72 hr. In addition, their leishmanicidal activity against amastigote forms was determined in a macrophage model, for 72 hr. Findings showed that the main components of essential oil were α-pinene (24.7%), 1,8-cineole (19.6%), and linalool (12.6%). Findings demonstrated that M. communis, particularly its essential oil, significantly (P<0.05) inhibited the growth rate of promastigote and amastigote forms of L. tropica based on a dose-dependent response. The IC50 values for essential oil and methanolic extract was 8.4 and 28.9 μg/ml against promastigotes, respectively. These values were 11.6 and 40.8 μg/ml against amastigote forms, respectively. Glucantime as control drug also revealed IC50 values of 88.3 and 44.6 μg/ml for pro...Continue Reading

Citations

Oct 10, 2015·Pharmaceutical Biology·Ebrahim Saedi DezakiFatemeh Ezatkhah
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Behrouz EzatpourFatemeh Ezzatkhah
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Farnaz KheirandishMarzieh Rashidipour
Aug 9, 2016·Surgical Infections·Hossein MahmoudvandHormoz Mahmoudvand
Jul 27, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Mekonnen Sisay, Tigist Gashaw
Nov 22, 2017·Scientia pharmaceutica·Mehrdad KhatamiManouchehr Khatami
Apr 5, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Majid S JabirUsama I Sahib
Dec 22, 2017·Pharmacognosy Research·Nasser A Awadh AliAbdulwali Al-Khulaidi
Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Emanuela Coutinho LunaFrancisco Jaime Bezerra Mendonça
Nov 24, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Farzaneh MirzaeiHamed Kalani
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raafat M ShaapanHossein Mahmoudvand
Mar 27, 2021·Acta Parasitologica·Aishah E AlbalawiFatemeh Ezzatkhah
Jul 24, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Elham ZarenezhadMahmoud Osanloo

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