Antileukemic activity of lignans and phenylpropanoids of Cinnamomum parthenoxylon

Bioorganic & Medicinal Chemistry Letters
Morina AdfaMamoru Koketsu

Abstract

In this study, we evaluated the in vitro cytotoxicity of fractions and isolated constituents from Cinnamomum parthenoxylon woods against human leukemia HL-60 and U937 cells. The n-Hex, EtOAc, and MeOH-H2O fractions of the woods inhibited cell proliferation in both cell lines. Our phytochemical investigation of the n-Hex and EtOAc fractions led to the isolation of lignans and phenylpropanoids, whose chemical structures were confirmed by spectroscopic analyses. All isolated compounds were evaluated for their in vitro antileukemic activity; especially, hinokinin and cubebin exhibited strong inhibition toward U937 cell proliferation. Morphological observation indicated that these cytotoxic actions were mediated by apoptosis. Our findings suggested that an oxygenated functional group at the C-9 position in dibenzylfuran skeleton contributed their potency. In addition, these results enhanced the ethnopharmacological value of C. parthenoxylon.

References

May 26, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Q JiaC Huang
Sep 11, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mehmet UnluNilufer Vural
Oct 4, 2013·Journal of Oleo Science·Dina Permata SariMamoru Koketsu

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Citations

Jun 8, 2017·Journal of Natural Products·Thomas MorauxChristine Gérardin-Charbonnier
Aug 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Carla MarcotullioJudith X Becerra
Oct 28, 2019·The Journal of Pharmacy and Pharmacology·Sanjay KumarShailja Mishra
Jun 25, 2021·Journal of Ethnopharmacology·Xiaohan WeiXiaomei Tan

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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis