PMID: 8957342Dec 1, 1996Paper

Antileukotriene therapy for asthma

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
J S Larsen, S K Jackson

Abstract

The role of leukotrienes (LTs) in asthma is reviewed, and research to develop anti-LT agents for this condition is described. Greater understanding of the role played by inflammatory cells and their mediators in the pathophysiology of asthma has shifted the emphasis of research from the bronchoconstriction component of the disease to the inflammatory one. LTs are believed to play a key role in the complex interplay of inflammatory cells that occurs in asthma. Inhibiting the production of LTs or blocking their receptor sites may decrease the inflammatory response and thereby provide a useful therapeutic modality. Three approaches have been used in attempts to affect the activity of LTs: inhibition of 5-lipoxygenase, inhibition of 5-lipoxygenase-activating protein, and LTD4-receptor antagonism. Investigational agents that have undergone clinical trials include zileuton (a 5-lipoxygenase inhibitor), MK-591 (a 5-lipoxygenase-activating protein inhibitor), and zafirlukast, pranlukast, and verlukast (three LT-receptor antagonists). Many studies suggest that these orally administered agents are effective, particularly with respect to the early asthmatic response to allergens and other challenges, and have a low adverse-effect profile;...Continue Reading

Citations

Jun 1, 2000·Indian Journal of Pediatrics·G Gupta
Sep 9, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·L García-Marcos, A Schuster
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ilknur BasyigitOktay Ozkarakas

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