Antilipidemic Drug Therapy Today and in the Future

Handbook of Experimental Pharmacology
W Kramer

Abstract

The armamentarium for the treatment of dyslipidemia today comprises six different modes of action with overall around 24 different drugs. The treatment of lipid disorders was revolutionized with the introduction of statins which have become the most important therapeutic option available today to reduce and prevent atherosclerosis and its detrimental consequences like cardiovascular diseases and stroke. With and optimized reduction of elevated LDL levels with statins, the risk for cardiovascular diseases (CVD) can be reduced by 30%, indicating a residual remaining risk of 70% for the development and progression of CVD notifying still a high medical need for more effective antilipidemic drugs. Consequently, the search for novel lipid-modifying drugs is still one of the most active areas in research and development in the pharmaceutical industry. Major focus lies on approaches to LDL-lowering drugs superior to statins with regard to efficacy, safety, and patient compliance and on approaches modifying plasma levels and functionality of HDL particles based on the clinically validated inverse relationship between high-plasma HDL levels and the risk for CVD. The available drugs today for the treatment of dyslipidemia are small organi...Continue Reading

Citations

Jul 2, 2019·Current Pharmaceutical Design·Ida Idayu MuhamadNurul Asmak Md Lazim

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Methods Mentioned

BETA
antisense oligonucleotide
FCS
sedation
biopsies
apheresis

Clinical Trials Mentioned

NCT01252953
NCT01284582

Software Mentioned

IMPROVE
IT
ODYSSEY

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