Antimalarial activity of allicin, a biologically active compound from garlic cloves.

Antimicrobial Agents and Chemotherapy
Alida CoppiPhotini Sinnis

Abstract

The incidence of malaria is increasing, and there is an urgent need to identify new drug targets for both prophylaxis and chemotherapy. Potential new drug targets include Plasmodium proteases that play critical roles in the parasite life cycle. We have previously shown that the major surface protein of Plasmodium sporozoites, the circumsporozoite protein (CSP), is proteolytically processed by a parasite-derived cysteine protease, and this processing event is temporally associated with sporozoite invasion of host cells. E-64, a cysteine protease inhibitor, inhibits CSP processing and prevents invasion of host cells in vitro and in vivo. Here we tested allicin, a cysteine protease inhibitor found in garlic extracts, for its ability to inhibit malaria infection. At low concentrations, allicin was not toxic to either sporozoites or mammalian cells. At these concentrations, allicin inhibited CSP processing and prevented sporozoite invasion of host cells in vitro. In vivo, mice injected with allicin had decreased Plasmodium infections compared to controls. When sporozoites were treated with allicin before injection into mice, malaria infection was completely prevented. We also tested allicin on erythrocytic stages and found that a 4-...Continue Reading

References

Sep 13, 1988·Journal of Immunological Methods·L RéniaD Mazier
Oct 1, 1981·The Journal of Experimental Medicine·N YoshidaR S Nussenzweig
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·H A PerezR Apitz
Jan 1, 1993·Annual Review of Microbiology·J H McKerrowJ Bouvier
Mar 1, 1993·The Journal of Clinical Investigation·P J RosenthalR E Smith
Nov 1, 1996·Applied and Environmental Microbiology·R NaganawaA Suzuki
Jun 3, 1999·Bioorganic & Medicinal Chemistry·J E OlsonP J Rosenthal
Jun 3, 1999·Bioorganic & Medicinal Chemistry·J H McKerrowC R Caffrey
Dec 14, 1999·Microbes and Infection·S Ankri, D Mirelman
Jan 29, 2000·Antimicrobial Agents and Chemotherapy·D JonkersE Stobberingh
Nov 22, 2001·The Biochemical Journal·P S SijwaliP J Rosenthal
Jan 5, 2002·Applied Microbiology and Biotechnology·J C HarrisD Lloyd
Jul 23, 2002·Current Pharmaceutical Design·Philip J RosenthalBhaskar R Shenai
Jul 1, 1956·The Biochemical Journal·E D WILLS
Dec 12, 2003·Molecular and Biochemical Parasitology·Joon Mo MyungPhotini Sinnis
Jul 22, 2004·Analytical Biochemistry·T MironD Mirelman
Jul 29, 2004·Molecular and Biochemical Parasitology·Blandine Franke-FayardChris J Janse
Jan 5, 2005·The Journal of Experimental Medicine·Alida CoppiPhotini Sinnis
Apr 27, 2005·Lancet·Brian M GreenwoodGeoffrey A T Targett
Jul 26, 2005·Infection and Immunity·Tatiana VozaLaurent Rénia
Jan 1, 1951·Advances in Enzymology and Related Subjects of Biochemistry·A STOLL, E SEEBECK

❮ Previous
Next ❯

Citations

Nov 1, 2013·Parasitology Research·Akram Ahmed SalamaIkuo Igarashi
Aug 23, 2008·Biological Trace Element Research·V Najar-NezhadM Balali-Mood
Apr 30, 2010·Journal of Chemical Information and Modeling·Sandhya KortagereLawrence W Bergman
Nov 30, 2011·Journal of Medicinal Chemistry·Tiago RodriguesFrancisca Lopes
Apr 25, 2013·Journal of Medicinal Chemistry·Roberta EttariPaola Conti
Nov 27, 2008·The Journal of Infectious Diseases·Charlotte V HobbsPhotini Sinnis
Jul 21, 2010·Antimicrobial Agents and Chemotherapy·Dhruv Panchal, Purnima Bhanot
Nov 7, 2012·Antimicrobial Agents and Chemotherapy·Alexis N LacrueDennis E Kyle
Jan 5, 2008·Infection and Immunity·Lisa A PurcellAna Rodriguez
Dec 25, 2008·Journal of Biomaterials Science. Polymer Edition·Dong Qing LuoChe Zhang
Feb 28, 2007·Journal of Ethnobiology and Ethnomedicine·Cheryl LansWilli Boepple
Dec 5, 2012·International Journal of Molecular Sciences·Sandro PercárioMichael D Green
Mar 1, 2012·Journal of Pharmacy & Bioallied Sciences·Vasim KhanK K Pillai
Mar 25, 2014·Natural Products and Bioprospecting·Lydia L LifongoPhilip N Judson
Feb 7, 2012·Journal of Immunological Methods·Satish MishraVictor Nussenzweig
Aug 10, 2010·Bioorganic & Medicinal Chemistry Letters·Thilo WaagTanja Schirmeister
Mar 21, 2009·Bioorganic & Medicinal Chemistry·Kirandeep KaurRahul Jain
Dec 18, 2007·International Journal of Antimicrobial Agents·Yun CaiYi Fang
Jan 6, 2011·Journal of Applied Microbiology·G Cruz-Villalón, C Pérez-Giraldo
Jun 12, 2010·Journal of Medical Microbiology·Mohsen Arzanlou, Shahab Bohlooli
Aug 29, 2012·Oxidative Medicine and Cellular Longevity·Yin LuDeyong Zhang
Oct 16, 2015·Jundishapur Journal of Microbiology·Zeinab Mohsenipour, Mehdi Hassanshahian
Apr 22, 2015·Parasitology Research·Atef Mohammed KhalilYoichiro Horii
Nov 3, 2010·Journal of Ethnopharmacology·Lastenia RuizVincent Roumy
Nov 26, 2010·Journal of Ethnopharmacology·J O Adebayo, A U Krettli
Apr 9, 2015·Frontiers in Immunology·Sarat Kumar DalaiAgam Prasad Singh
Jun 4, 2014·Molecular and Biochemical Parasitology·Babu S MastanKota Arun Kumar
Dec 28, 2010·Toxicon : Official Journal of the International Society on Toxinology·M ArzanlouH Mirzanejad-Asl
May 2, 2012·Asian Pacific Journal of Tropical Medicine·Balaji MerigaT MuraliKrishna
Sep 22, 2012·Experimental Parasitology·María Jesús Corral-CaridadJosé María Alunda
Mar 31, 2016·PLoS Neglected Tropical Diseases·María J CorralJosé M Alunda
Jan 2, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Masoud Foroutan-RadShahram Khademvatan
Aug 10, 2019·Journal of Vector Borne Diseases·Victor N OguguaPeter N Uzoegwu
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MiękusArtur H Świergiel
Oct 31, 2018·Frontiers in Cellular and Infection Microbiology·Raúl Argüello-GarcíaM Guadalupe Ortega-Pierres

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