PMID: 7020445May 1, 1981Paper

Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro

The American Journal of Tropical Medicine and Hygiene
W Trager, J Polonsky

Abstract

The growth of Plasmodium falciparum in vitro was markedly inhibited by certain quassinoids (the bitter principles from plants of the family Simaroubaceae). The most active compound, simalikalactone D, gave complete inhibition at 0.005 microgram/ml. Glaucarubinone an soularubinone were equally effective at 0.006 microgram/ml, whereas chaparrinone and simarolide had little effect even at 0.01 microgram/ml. These relative activities are parallel to the antineoplastic activities of these materials.

Citations

Aug 1, 1983·Annals of Tropical Medicine and Parasitology·P Y GuruJ D Phillipson
Jan 1, 2000·Pharmaceutical Biology·L Villaescusa-CastilloG Balansard
Nov 28, 2008·The Journal of Antimicrobial Chemotherapy·Surajit BhattacharjeeSubrata Majumdar
Oct 1, 1984·Journal of Chemical Ecology·V LeskinenS Bhatnagar
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Aug 9, 2006·Reproductive Medicine and Biology·Yinusa RajiMistura O Azeez
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