PMID: 3009719Jan 1, 1986Paper

Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei

Journal of Natural Products
Y ZhaoK H Lee

Abstract

The activity of the cytochrome oxidase, which is located in the plasma and the nuclear and the food-vacuole-limiting membranes as well as in the mitochondria of the trophozoites of Plasmodium berghei, was inhibited completely by sodium artesunate, an antimalarial drug, in vitro at 1 mM and in vivo at 100 mg/kg iv. This enzyme appears to be a target for the antimalarial mechanism of action of artesunate and qinghaosu.

Citations

Oct 19, 1990·Pharmaceutisch Weekblad. Scientific Edition·H J WoerdenbagN Pras
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·S R Krungkrai, Y Yuthavong
Mar 31, 2015·Molecular BioSystems·QingMing KongShaoHong Lu

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