Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108

Natural Product Research
Sasiphimol SawadsitangSirirath Sodngam

Abstract

Xylaria cf. cubensis PK108 was identified by its distinctive morphological characteristics and its internal transcribed spacers sequence analysis. The chromatographic separation and structural elucidation based on spectroscopic analysis of fungal crude extracts led to 10 compounds; tryptoquivaline L (1), fiscalin C (2), epi-fiscalin C (3), cytochalasin D (4), ergosterol (5), ergosterol peroxide (6), chevalone C (7), xylaranol B (8), helvolic acid (9) and cyclo-(L-Pro-L-Leu) (10). The bioassay screening showed that 4 displayed cytotoxicity against KB and NCI-H187 cancer cell lines with IC50 values of 3.25 and 5.95 μg mL(-1). 6 exhibited cytotoxicity against NCI-H187 with an IC50 value of 5.81 μg mL(-1). 7 and 9 showed antimalarial activity with IC50 values of 25.00 and 6.25 μg mL(-1), respectively. This result establishes Xylaria as broad spectrum bioactive compound producers.

References

Mar 1, 1996·Journal of Natural Products·G S JayatilakeB J Baker
Jun 1, 2005·Journal of Natural Products·Rohan A Davis
Nov 6, 2007·Chemical & Pharmaceutical Bulletin·Wipapan PongcharoenKanlayanee Sriklung
Apr 11, 2012·Journal of Natural Products·Séverine AmandSoizic Prado
Aug 7, 2012·Archives of Pharmacal Research·Saranyoo KlaiklayBoonsom Bussaban

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Citations

Jul 1, 2016·Natural Product Research·Xiao LinLianru Zhang
Nov 22, 2016·Natural Product Research·Sirirath McCloskeyUma Prawat
Jan 10, 2017·Natural Product Research·Abdou TchoukouaYoshihito Shiono
Jan 11, 2017·Natural Product Research·Xiaowei LuoYonghong Liu
Apr 8, 2017·Natural Product Research·Na ZhengRuiyun Yang
May 11, 2017·Natural Product Research·Chuan-Wen LeiXiao-Hong Yuan
Nov 25, 2017·Natural Product Research·Sasiphimol SawadsitangSirirath McCloskey
May 18, 2018·Natural Product Research·Sheng-Yan QianGui-Guang Cheng
Oct 13, 2017·Natural Product Research·Chenjia GuoXiaoyi Wei
Oct 17, 2018·Rapid Communications in Mass Spectrometry : RCM·Jacob P WalshMark W Sumarah
Nov 30, 2018·Marine Drugs·Chang-Liang AnYou-Xing Zhao

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Datasets Mentioned

BETA
HE863948
CBS116.85

Methods Mentioned

BETA
NMR

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