Antimalarial and cytotoxic drugs on COVID-19 and the cardiovascular burden: Literature review and lessons to be learned.

Vascular
Sherif Sultan, Yogesh Acharya

Abstract

The world is witnessing an unprecedented crisis with Coronavirus disease 2019 (COVID-19). It is important to accurately analyze the available evidence to provide correct clinical guidance for optimal patient care. We aim to discuss current clinical evidence regarding chloroquine, hydroxychloroquine, azithromycin, remdesivir, and the cardiovascular burden of COVID-19. A literature review was performed using PubMed and Google Scholar. Additional clinical trials were identified through the "TrialsTracker" project. We found conflicting evidence of chloroquine, hydroxychloroquine plus azithromycin, and remdesivir in COVID-19 despite promising early reports of in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2. Some of the current studies have demonstrated adverse drug reactions to chloroquine and hydroxychloroquine + azithromycin. Widespread systemic inflammation and procoagulant/hypercoagulable state, including thrombotic microangiopathy, endothelial dysfunction, bleeding disorder, and thrombosis are increasingly being witnessed in COVID-19. Evidence of cardiac injury and stroke is mostly reported in hospitalized patients; however, large specialized studies that focus on cardiac or neuropathology ar...Continue Reading

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Citations

Nov 27, 2020·Curēus·Anupam K GuptaJohn Parker

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT04323527
NCT04315948
NCT04324463
NCT04308668
NCT04318444
NCT04292899
NCT04292730

Software Mentioned

Google Scholar
TrialsTracker

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