Antimalarial drugs inhibit the phagocytosis of erythrocytes infected with Plasmodium falciparum

Transactions of the Royal Society of Tropical Medicine and Hygiene
G ShalmievH Ginsburg

Abstract

Phagocytic cells constitute the first line of defence against malarial parasites. They perform their role by delivering oxidative radicals and by phagocytosing infected red blood cells (IRBC). Phagocytosis is mediated by antibody binding to clustered band 3 antigen in the IRBC membrane and activation of the alternative complement pathway. In this study we showed that treatment of IRBC containing Plasmodium falciparum with therapeutically-relevant concentrations of antimalarial drugs considerably reduced the binding of immunoglobulin G (IgG) to, and the phagocytosis of, IRBC. Opsonization of IRBC by fresh serum before drug treatment prevented this inhibitory action of drugs. Removal of the drug restored IgG binding and the phagocytic susceptibility of IRBC in a time-dependent fashion. Direct measurement of the effect of chloroquine on the clustering of band 3 in IRBC, however, failed to reveal any disruption of the aggregation. We conclude that antimalarial drugs are able to alter, by an as yet unresolved mechanism, the affinity of IgG to clustered band 3. This affinity of IRBC seems to be determined by a dynamic process that depends on the metabolic activity of the parasite.

References

Jan 1, 1990·Critical Reviews in Oncology/hematology·T ShigaK Kon
Mar 1, 1989·Parasite Immunology·M Ho, H K Webster
Jan 1, 1988·Journal of Cell Science. Supplement·S GordonH Rosen
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H U LutzP Arese
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E WinogradI W Sherman
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·R N PrasadR C Mahajan
Apr 3, 1995·FEBS Letters·C SignoriniM Comporti
Jan 1, 1993·Annual Review of Microbiology·J H McKerrowJ Bouvier
Oct 1, 1993·Molecular and Biochemical Parasitology·H Atamna, H Ginsburg

❮ Previous
Next ❯

Citations

Sep 29, 1999·International Journal of Immunopharmacology·J P Goldring, S Nemaorani
Jul 18, 2021·Malaria Journal·Caroline Lin Lin ChuaAndrew Teo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.