Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide)

Bioorganic & Medicinal Chemistry Letters
Kanji FujimotoKenji Sasaki

Abstract

The in vitro antimalarial activity of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide) and their derivatives, against the Plasmodium falciparum FCR-3 strain (ATCC 30932, chloroquine-sensitive) was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 3.5microM to 10nM. The chain length of the N1-alkyl moiety was found to be very beneficial in terms of antimalarial activity, and in this series of compounds, the most appropriate N1-alkyl chain length was found to be eight.

References

Jun 17, 2000·International Journal for Parasitology·K T AndrewsP G Parsons

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Citations

Mar 12, 2008·Journal of Oleo Science·Parag Madaan, Vinod K Tyagi
Nov 3, 2010·Chemical Biology & Drug Design·Sandip B Bharate, Charles M Thompson
Mar 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lijie WeiZhanyong Guo

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