PMID: 1091172Mar 1, 1975

Antimalarial effects of clindamycin in man

The American Journal of Tropical Medicine and Hygiene
D F ClydeV C McCarthy

Abstract

Clindamycin 450 mg every 8 hours for 3 days cured three non-immune patients of falciparum malaria, although the response was slow. The addition of quinine to this regimen provided an accelerated response and cured 3 of 5 other patients. Single doses of clindamycin given daily for 3 days, with or without quinine, cured 1 of 3 patients. Gastric intolerance to the drugs, probably accentuated by the clinical condition, was pronounced in some cases, the course of treatment being interrupted in three patients for this reason. Chesson strain Plasmodium vivax relapses in man were not inhibited by ingestion of 450 mg of clindamycin every 6 hours for 14 days.

References

Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Bertrand Lell, Peter G Kremsner
Jun 10, 2016·Scientific Reports·Charisse Flerida A PasajeStuart A Ralph
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Ravit Arav-Boger, Theresa A Shapiro
Mar 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J W Smith
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Rolfe
Aug 10, 2005·Expert Opinion on Pharmacotherapy·Timothy R Pasquale, James S Tan

Related Concepts

Antimalarial [EPC]
Cinchona pubescens
Plasmodium vivax
Intolerance Function
Malaria, Falciparum
Malaria
Quinine
Dalacin C
Quinbisan
Ingestion

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