PMID: 22574553May 12, 2012Paper

Antimalarial-induced maculopathy: accuracy of Amsler grid as a diagnostic tool and risk factors

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Praveena ChiowchanwisawakitNgamkae Ruangvaravate

Abstract

To determine the sensitivity, specificity, and agreement of Amsler grid (AG) in detecting antimalarial induced maculopathy (AM) compared to combination of dilated ocular examination and Humphrey visual field (HVF) 10-2 and to estimate the risk factors of AM. 20 patients with AM and 20 patients with no AM were included between October 1, 2010 and June 30, 2011 in Siriraj Hospital, Thailand. Sensitivity, specificity and unweighted kappa were used to determine accuracy of AG. Logistic regression was used to explore risk factors associated with AM. The sensitivity and specificity of AG were 40% and 100%, respectively. The agreement of AG and HVF 10-2 was poor with kappa of 0.4. Creatinine clearance < 60 ml/min/1.73 m2 and bilateral macular abnormality were associated with AM at the same odds ratio of 8.9 (95% confidence interval: 1.3 to 61.2). AG may be used as an additional test between ocular evaluation visits providing the availability and low cost. Patients with renal impairment and bilateral macular abnormality are associated with AM.

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Arquivos brasileiros de oftalmologia
Bruno Vargas MadalenaPedro Durães Serracarbassa
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
T J McCulleyW J Feuer
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Apichat Suansilpong, Somchai Uaratanawong
© 2021 Meta ULC. All rights reserved