Antimalarials in rheumatic diseases

Baillière's Clinical Rheumatology
S E TettR Day

Abstract

The antimalarials hydroxychloroquine and chloroquine remain established and effective agents for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Although the mechanisms of action remain uncertain, evidence is accumulating that the antirheumatic and immunological effects of the antimalarials are related to their massive distribution into the cellular acid-vesicle system. These drugs are attracting new interest because their relative safety recommends their use in early rheumatoid arthritis and as a component of second-line antirheumatic drug combinations. The absence of data examining the effect of antimalarials upon radiological progression of rheumatoid arthritis needs to be rectified. Recent understanding of the pharmacokinetics of these drugs reveals that steady-state concentrations are not achieved for at least 3-4 months. Preliminary information also suggests a relationship between blood concentrations and effect. Taken together, these data suggest that more effective dosage regimens will be possible when therapeutic concentration ranges are properly established.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S Ohkuma, B Poole
Mar 1, 1979·Clinical Pharmacology and Therapeutics·M Frisk-HolmbergF Jansson
Mar 1, 1977·Arthritis and Rheumatism·I L DwoshM A Ogryzlo
Feb 15, 1990·Biochemical Pharmacology·V Ferrari, D J Cutler
Jul 1, 1990·British Journal of Pharmacology·M G PerssonS Moncada
Jun 1, 1989·British Journal of Clinical Pharmacology·S E TettK F Brown
Mar 1, 1986·Annals of the Rheumatic Diseases·Y MiyachiY Niwa
Oct 14, 1988·The American Journal of Medicine·A Parke
Oct 14, 1988·The American Journal of Medicine·N Rothfield
Aug 27, 1987·The New England Journal of Medicine·D J Krogstad, P H Schlesinger
Mar 1, 1988·Journal of Pharmaceutical Sciences·A C MacIntyre, D J Cutler
Jan 1, 1986·Journal of Clinical Pharmacology·D G Baker, J L Rabinowitz
Jan 1, 1987·European Journal of Clinical Pharmacology·S E Tett, D J Cutler
Mar 1, 1987·British Journal of Clinical Pharmacology·O WalkerF Sjöqvist
May 1, 1987·Arthritis and Rheumatism·D R MillerV J Stecher
Aug 1, 1987·British Journal of Clinical Pharmacology·L L GustafssonG Alván
Sep 1, 1986·British Journal of Clinical Pharmacology·D Ofori-AdjeiF Sjöqvist
Nov 1, 1986·Journal of Pharmaceutical Sciences·A C MacIntyre, D J Cutler
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·M LagraveB Betschart
Sep 15, 1974·Biochemical Pharmacology·C de DuveF Van Hoof
Mar 1, 1973·Clinical Orthopaedics and Related Research·P S VolastroO D Chrisman
Jul 1, 1973·Annals of the Rheumatic Diseases·G S PanayiJ N McCormick
Nov 1, 1973·Annals of the Rheumatic Diseases·W A NeillR J Prescott
Sep 1, 1974·Southern Medical Journal·V J Di Maio, L D Henry
Oct 1, 1968·Experimental and Molecular Pathology·R AbrahamP Grasso
Nov 11, 1965·The New England Journal of Medicine·G Weissmann
Nov 18, 1965·The New England Journal of Medicine·G Weissmann
Oct 1, 1968·American Journal of Ophthalmology·R E CarrI M Siegel
Sep 3, 1965·Science·J L AllisonF E Hahn
Aug 1, 1966·The Journal of Experimental Medicine·P A Ward
Aug 1, 1967·American Journal of Ophthalmology·R V Shearer, E L Dubois
Jul 1, 1981·The Journal of Pharmacy and Pharmacology·D G Trist, M Weatherall

❮ Previous
Next ❯

Citations

Feb 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C AugustS Schröder
Jan 1, 1993·European Journal of Clinical Pharmacology·A J McLachlanS E Tett
Jun 10, 2000·British Journal of Clinical Pharmacology·M SomerM Scheinin
Apr 14, 2010·Molecular Medicine·Hanna SchierbeckHelena Erlandsson Harris
Mar 17, 2016·Legal Medicine·Muhammad ImranMuhammad Ashraf Tahir
Dec 1, 2007·Journal of Biochemistry and Molecular Biology·Myung-Min ChoiSeung-Ju Yang
Mar 9, 2018·Current Opinion in Rheumatology·Nada AbdulazizWilliam J McCune
Nov 26, 2003·Therapeutic Drug Monitoring·Samantha J CarmichaelSusan E Tett
Apr 1, 1993·Australian and New Zealand Journal of Medicine·P M Brooks
Feb 14, 2018·The Journal of Pharmacology and Experimental Therapeutics·Keagan P CollinsDaniel L Gustafson
Mar 5, 2017·Drug Safety - Case Reports·Ciro ManzoAlberto Castagna
Jun 25, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Dhrubajyoti BandyopadhyaySrihari S Naidu
Feb 3, 2021·Biological Procedures Online·Jyoti ChoudharyNitin Baliyan
Feb 16, 2021·World Journal of Virology·Asim KichlooAkif Kichloo
Oct 31, 2020·Pharmacogenomics and Personalized Medicine·Mariana Babayeva, Zvi Loewy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.