Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer

Journal of the National Cancer Institute
N KunduA M Fulton

Abstract

Interleukin 10 (IL-10) is a potent immunoregulatory cytokine. It inhibits some cell functions, including T-helper (Th1) cell activity (i.e., interleukin 2 and interferon gamma production), and stimulates other functions such as a natural killer (NK) activity. In mice, IL-10 suppresses tumorigenicity in a xenograft system using a nonmetastasizing hamster cell line. We evaluated the antitumor and antimetastatic properties of IL-10 in syngeneic immunocompetent and immunocompromised murine hosts. Using the plasmids pBMGneo and pBMGneo.IL-10, we transfected the highly malignant murine mammary tumor cell lines 410.4 and 66.1 (transfectants designated as 410.4-IL10 and 66.1-IL10, respectively) to stably express IL-10 (2-100 U IL-10/2.5 x 10(5) cells per 48 hours). Tumorigenic and metastatic activities of the parent and transfected cells w ere measured in immunocompetent, syngeneic BALB/cByJ mice as well as in immunocompromised C.B-17/IcrCrl-SCID/Beige mice. Tumor growth was completely inhibited following inoculations of 5 x 10(6)410.4-IL10 cells in immunocompetent, syngeneic BALB/cByJ mice. This inoculum contains 100 times the minimum cell number required for 100% tumor incidence. In contrast, tumor growth following the inoculation of...Continue Reading

Citations

Jun 4, 1998·International Journal of Cancer. Journal International Du Cancer·N KunduA M Fulton
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·S MocellinF M Marincola
Nov 8, 2011·Breast Cancer Research and Treatment· HamidullahRituraj Konwar
Dec 6, 2011·Immunologic Research·Takami SatoSenthamil R Selvan
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Sep 2, 1998·Transplantation Proceedings·A el GamelI V Hutchinson
Dec 4, 2003·Biochimica Et Biophysica Acta·Simone MocellinFrancesco M Marincola
Apr 1, 1997·Critical Reviews in Oncology/hematology·T Tanaka
Sep 1, 1997·Urologic Oncology·N NishisakaG P Haas
Jun 29, 2001·Trends in Immunology·R B BankertS D Hess
Dec 24, 2002·Trends in Immunology·Simone MocellinFrancesco M Marincola
Jun 1, 1997·Breast Cancer Research and Treatment·J M RuppertT V Strong
Aug 24, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S HuangM Bar-Eli
Oct 1, 2013·Current Opinion in Oncology·Kristen L DennisKhashayarsha Khazaie
Sep 21, 2004·Journal of Gastroenterology and Hepatology·Keishi FujiwaraYasushi Shiratori
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Apr 20, 2011·Journal of Innate Immunity·Ana Stojanovic, Adelheid Cerwenka
May 11, 2010·Molecular Medicine·Karoline LipnikChristine Hohenadl
Nov 8, 2011·Immunotherapy·Judith LeiboviciJudith Sinai
Apr 2, 2011·World Journal of Gastroenterology : WJG·Jie LiuZhe-Hai Wang
Feb 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lei JinGuojun Li
Dec 1, 2001·Expert Opinion on Biological Therapy·G Q PhanF M Marincola
Jan 22, 2003·The Journal of Investigative Dermatology·Eric AlamartineFrançois Berthoux
Mar 3, 2007·Cytokine & Growth Factor Reviews·Flavio Salazar-OnfrayAriadna Mendoza-Naranjo
Feb 27, 2007·Cytokine & Growth Factor Reviews·Osvaldo L PodhajcerGuillermo Mazzolini
May 29, 2008·International Journal of Cancer. Journal International Du Cancer·Ivan ShaboJoar Svanvik
May 15, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John B Mumm, Martin Oft
Feb 26, 2011·Immunological Reviews·Graham A W Rook, Angus Dalgleish
Jul 19, 2015·Cancer Letters·Mark H ManninoYujiang Fang
May 19, 2012·Immunological Investigations·Patricia A Masso-WelchShiu-Ming Kuo
Jun 19, 2013·Radiation Research·Tomonori HayashiKei Nakachi
Jul 30, 2014·Cell Reports·Michelle ElvingtonStephen Tomlinson
Aug 4, 2016·Cancer Medicine·Shannon M ConroyChristine M Friedenreich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.