Antimetastatic and growth-inhibitory effects of N-acetylchitohexaose in mice bearing Lewis lung carcinoma

Japanese Journal of Cancer Research : Gann
K TsukadaM Suzuki

Abstract

N-Acetylchitohexaose, a water-soluble oligosaccharide was found to display a significant antimetastatic effect against Lewis lung carcinoma (LLC) transplanted into C57BL/6 mice, giving rise to a 40-50% inhibition ratio of pulmonary metastasis when administered intravenously (1 mg/kg) on day 6 after the tumor implantation (5 x 10(5) cells/mouse). It was also revealed that this hexaose had a significant growth-inhibitory effect against the local tumor of the same carcinoma (a 20-30% inhibition ratio), showing an enhancing effect on concomitant immunity in local tumor-resected mice. This oligosaccharide was also shown to enhance the tumoricidal effect of splenic T lymphocytes against LLC and P-815 mastocytoma cells and to increase the natural killer activity of splenic T lymphocytes, assayed with YAC-1 cells as the target.

References

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Citations

Apr 29, 2006·Applied Microbiology and Biotechnology·Y S LeeY L Choi
Jul 18, 2006·Journal of Zhejiang University. Science. B·Li ZhangDong-feng Wang
Aug 18, 2010·Marine Drugs·Jiali ZhangBo Li
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Apr 6, 2004·Biochemical and Biophysical Research Communications·Jie FengQiqi Yu
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·Yuanqing XuJunliang Li
Mar 3, 2015·Applied Biochemistry and Biotechnology·Takamitsu MinamotoToshiyuki Nishio
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Oct 17, 2014·Journal of breast cancer·Leila RezakhaniMozafar Khazaei
Feb 27, 2019·The Journal of Microbiology·Dawoon ChungJaejoon Jung
Jun 12, 2009·Immunopharmacology and Immunotoxicology·Sheng SongWei R Chen
Nov 10, 2006·Molecular Biology Reports·Fuyun ZhangYukui Zhang
Jan 31, 2002·World Journal of Gastroenterology : WJG·Yi-Ping LiuMeng-Chen Cai
Jan 30, 2019·International Journal of Biomaterials·Hari Sharan Adhikari, Paras Nath Yadav
Nov 13, 2008·Biomacromolecules·João C FernandesF Xavier Malcata

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