Antimetastatic and immunomodulating effect of water extracts from various mushrooms

Journal of Acupuncture and Meridian Studies
Sung-Soo Ronald HanHwa-Seung Yoo

Abstract

This experiment was conducted to evaluate inhibitory effects against lung metastasis and promotion of splenocytes by water extracts from various mushrooms including Armillaria mellea, Grifola frondosa, Garnoderma frondosa, Codyceps militaris, Hericium erinaceus, Coriolus versicolor, Agaricus Blazei with Lycium Chinense Miller (known as M8). Analysis of carbohydrate using HPTLC showed that beta-glucan and pachyman were some of the major components of M8. Oral administration of M8 resulted in a dose-dependent tendency to inhibit lung metastasis after intravenous injection of colon26-L5 cells. Treatment with M8 resulted in a significant increase of T cell and B cell mitogenic stimuli. The population of CD3, CD19, CD4, and CD8 positive cells increased in a dose dependent manner of M8 administration. However, no significant results were obtained from the population of Mac-1 and NK1.1 positive cells. Oral administration of M8 resulted in the increased production of IFN-gamma and IL-4 by splenocytes stimulated with Con A compared with untreated controls. These results show that M8 has antitumor activities which may be useful as an antimetastatic agent.

References

Jun 1, 1991·The Journal of Experimental Medicine·J K Czop, J Kay
Apr 1, 1986·Chemical & Pharmaceutical Bulletin·N OhnoT Yadomae
Jan 1, 1993·Advances in Immunology·M C Miceli, J R Parnes
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
May 8, 1998·Bioscience, Biotechnology, and Biochemistry·M MizunoH Tsuchida
Sep 8, 1999·The Journal of Experimental Medicine·T NishimuraA Ohta
Jan 4, 2001·Japanese Journal of Pharmacology·K ShigesueH Nanba
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Hyun Ja KimBo Youl Choi
Oct 19, 2002·Urology·Ralph W deVere WhiteBuxiang Sun
Nov 19, 2002·Applied Microbiology and Biotechnology·S P Wasser
Feb 15, 2003·International Immunopharmacology·Soo Jin LeeSung-Hoon Kim
Sep 23, 2003·Biotechnology Advances·Jian Cui, Yusuf Chisti
Feb 24, 2004·Journal of Medicinal Food·Noriko KodamaHiroaki Nanba
Apr 21, 2004·Experimental Biology and Medicine·Andrea T BorchersM Eric Gershwin
Dec 28, 2004·Journal of Ethnopharmacology·Ki-Tae HaCheorl-Ho Kim
Feb 24, 2005·Applied Microbiology and Biotechnology·Ben-Zion ZaidmanSolomon P Wasser
Jul 16, 2005·Blood·Heddy ZolaHilary Warren
Apr 6, 2006·Biological & Pharmaceutical Bulletin·Haemi LeeTaesun Park
Jun 20, 2006·International Immunopharmacology·Chang Gue SonSeung Hyun Han
Jul 27, 2006·Acta Pharmacologica Sinica·Chang-Gue SonSeung-Hyun Han
Aug 30, 2008·International Immunopharmacology·Zhisong ChenSoh Ha Chan

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Citations

Jan 18, 2014·Journal of Medicinal Food·Hirokazu TsuboneSho Amano
Apr 14, 2015·Seminars in Cancer Biology·W G JiangD Santini
Dec 1, 2011·Immunopharmacology and Immunotoxicology·Young-Ock KimYun-Hee Rhee
Mar 24, 2015·Journal of Medicinal Food·Etsuko HaradaEsteban C Gabazza
Aug 17, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R G P T JayasooriyaGi-Young Kim
Mar 18, 2017·Investigational New Drugs·Raheleh RoudiMonireh Mohsenzadegan
Apr 13, 2017·Laboratory animal research·Joo-Hee ChoiJong-Hwan Park
Jan 8, 2013·International Journal of Molecular Medicine·Hye-Ryung ParkKwang-Soon Shin
Jul 8, 2017·Current Medicinal Chemistry·Manee Patanapongpibul, Qiao-Hong Chen
Jul 23, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Mateusz WinderJerzy Chudek

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