Antimicrobial activities of ethanol and butanol fractions of white rose petal extract

Regulatory Toxicology and Pharmacology : RTP
Dongsun ParkYun-Bae Kim

Abstract

White rose (Rosa hybrida) petals were extracted with ethanol (EtOH) or butanol (BuOH), and tested for their antimicrobial activities against two species of Gram-positive bacteria, six species of Gram-negative bacteria, and two species of fungi. On in vitro antimicrobial assays, Helicobacter pylori and Propionibacterium acnes were highly susceptible to white rose petal extract (WRPE)-EtOH and WRPE-BuOH, leading to minimal inhibitory concentrations of 100 and 10 μg/mL for H. pylori and 400 and 40 μg/mL for P. acnes, respectively. In in vivo experiments, C57BL/6 mice were infected with H. pylori by intragastric inoculation (1 × 10(8) CFU/mouse) 3 times, and orally treated twice a day for 14 days with WRPE-EtOH and WRPE-BuOH. On a CLO kit assay, 200 mg/kg of WRPE-EtOH fully eliminated the bacteria from the gastric mucosa, and the effect of 100 mg/kg of ethanol fraction was similar to pantoprazole (30 mg/kg), displaying 75% elimination. WRPE-BuOH was more effective, exhibiting 75% elimination at 20 mg/kg. The CLO test results were confirmed by bacterial identification. WRPE-EtOH and WRPE-BuOH inhibited the growth of various bacteria and fungi, and in particular, they effectively killed H. pylori and eliminated the bacteria from the ...Continue Reading

References

Feb 8, 2000·Journal of Ethnopharmacology·P C DiasJ E de Carvalho
Nov 9, 2001·Microbiology·G A StrobelC Markworth
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ludmila FilaretovaKoji Takeuchi
Aug 20, 2003·Alimentary Pharmacology & Therapeutics·K B HahmS W Cho
Nov 26, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dongsun ParkSeong Soo Joo
Mar 12, 2010·World Journal of Gastroenterology : WJG·Zhan ZhangPing-Chang Yang
Jul 3, 2013·Journal of the Science of Food and Agriculture·Renata NowakJolanta Rzymowska

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